Irlenbusch U, Forke L, Fuhrmann U, Lorenz U, Stechel A
Orthopädische Klinik, Marienstift Arnstadt, Wachsenburgallee 12, 99310 Arnstadt.
Z Rheumatol. 2010 Aug;69(6):544-9. doi: 10.1007/s00393-010-0643-z.
The definition of generalized osteoarthritis in the literature is just as controversial as the discussion about correlations between GOA and Heberden's nodes (HN). Therefore, both questions were investigated in patients with proven heredity in a genealogical study of 931 family members.
In 106 patients with HN and 109 control subjects, 70 joints and spinal segments were investigated with respect to characteristic functional parameters. In addition, 44 joints and spinal segments were investigated radiologically.
GOA affects both the small and large joints as well as the spine. This phenomenon is the more pronounced the more finger joints are affected by Heberden's and Bouchard's nodes.
GOA affects the entire musculoskeletal system. The varying manifestation in individual joints and spinal segments is probably attributable to multifactorial local and systemic factors. In an earlier study, a genetic disposition with a maximum HA prevalence of 30% was identified in the study population. Since HA is considered a genetic marker for GOA, it can be assumed that the same is true of GOA prevalence.
文献中关于全身性骨关节炎的定义与关于全身性骨关节炎（GOA）和赫伯登结节（HN）之间相关性的讨论一样具有争议性。因此，在一项对931名家庭成员的系谱研究中，对有明确遗传史的患者进行了这两个问题的调查。
对106例有赫伯登结节的患者和109例对照者的70个关节和脊柱节段进行了特征性功能参数调查。此外，对44个关节和脊柱节段进行了放射学检查。
全身性骨关节炎影响小关节和大关节以及脊柱。赫伯登结节和布夏尔结节对指关节的影响越严重，这种现象就越明显。
全身性骨关节炎影响整个肌肉骨骼系统。各个关节和脊柱节段表现的差异可能归因于多因素的局部和全身因素。在早期的一项研究中，在研究人群中确定了遗传易感性，其中遗传性骨关节炎（HA）的最高患病率为30%。由于遗传性骨关节炎被认为是全身性骨关节炎的遗传标记，可以假定全身性骨关节炎的患病率也是如此。
