Malov Iu S, Kulikov A N
Ter Arkh. 1991;63(2):34-7.
An important role in the protection of the gastric and duodenal mucosa is played by bicarbonates. Gastric secretion of bicarbonates was examined in 42 patients with gastroduodenal pathology. Basal secretion of bicarbonates by the stomach was approximately the same (0.84 +/- 0.07 mmol/h) in patients with chronic gastritis, gastroduodenitis and peptic ulcer. After stimulation of gastric glands with a 5% alcoholic solution gastric secretion of bicarbonates increased in patients with chronic gastritis whereas in patients with peptic ulcer and gastroduodenitis, it significantly reduced. A inverse relationship was discovered between bicarbonate production and hydrochloric acid secretion. In patients with peptic ulcer, the reduction of bicarbonate and mucus output by the stomach is viewed as one of the mechanisms of ulcerogenesis.
碳酸氢盐在保护胃和十二指肠黏膜方面发挥着重要作用。对42例胃十二指肠疾病患者的胃碳酸氢盐分泌情况进行了检查。慢性胃炎、胃十二指肠炎症和消化性溃疡患者胃碳酸氢盐的基础分泌量大致相同（0.84±0.07毫摩尔/小时）。用5%酒精溶液刺激胃腺后，慢性胃炎患者的胃碳酸氢盐分泌增加，而消化性溃疡和胃十二指肠炎症患者的胃碳酸氢盐分泌则显著减少。发现碳酸氢盐生成与盐酸分泌之间呈负相关。在消化性溃疡患者中，胃碳酸氢盐和黏液分泌减少被视为溃疡形成的机制之一。
