Vadgama P, Alberti K G
Digestion. 1983;27(4):203-13. doi: 10.1159/000198954.
The surface epithelial cells of the gastroduodenal mucosa are thought to be protected from the damaging effects of acid by a covering layer of mucus into which is secreted bicarbonate. It is proposed here that mucus acts as a true barrier to hydrogen ion diffusion, and that the role played by bicarbonate is to adjust mucus pH to a range at which this barrier property is optimized. It is further proposed that a high content of luminal bicarbonate will promote the transfer of protons across mucus by a buffer shuttle mechanism, and that this may be the basis for the development of peptic ulceration.
胃十二指肠黏膜的表面上皮细胞被认为受到一层黏液覆盖层的保护，使其免受酸的破坏作用，黏液中会分泌碳酸氢盐。本文提出，黏液作为氢离子扩散的真正屏障，而碳酸氢盐的作用是将黏液的pH值调节到该屏障特性最优化的范围。还进一步提出，管腔内高含量的碳酸氢盐会通过缓冲穿梭机制促进质子穿过黏液的转移，而这可能是消化性溃疡发生的基础。
