Wang Hong, Wu Baoming, Liu Ding
Research Institute of Surgery & Daping Hospital of the Third Military Medical Unioersity, Chongqing 400042, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2010 Apr;27(2):278-82.
In order to overcome the existing shortcomings of the non-invasive blood glucose polarized light measurement methods of optical heterodyne detection and direct detection, we present in this paper a new orthogonal twin-polarized light (OTPL) non-invasive blood glucose measurement method, which converts the micro-angle rotated by an optical active substance such as glucose to the energy difference of OTPL, amplifies the signals by the high-sensitivity lock-in amplifier made of relevant principle, controls Faraday coil current to compensate the changes in deflection angle caused by blood glucose, and makes use of the linear relationship between blood glucose concentration and Faraday coil current to calculate blood glucose concentration. In our comparative experiment using the data measured by LX-20 automatic biochemical analyzer as a standard, a 0.9777 correlation coefficient is obtained in glucose concentration experiment, and a 0.952 in serum experiment. The result shows that this method has higher detection sensitivity and accuracy and lays a foundation for the development of practical new type of non-invasive blood glucose tester for diabetic patients.
为克服光学外差探测和直接探测的无创血糖偏振光测量方法存在的缺点，本文提出一种新型正交双偏振光（OTPL）无创血糖测量方法，该方法将葡萄糖等旋光物质旋转的微小角度转换为正交双偏振光的能量差，利用相关原理制成的高灵敏度锁相放大器对信号进行放大，控制法拉第线圈电流补偿血糖引起的偏转角变化，并利用血糖浓度与法拉第线圈电流之间的线性关系计算血糖浓度。在以LX - 20自动生化分析仪测量数据为标准的对比实验中，葡萄糖浓度实验获得的相关系数为0.9777，血清实验为0.952。结果表明，该方法具有较高的检测灵敏度和准确性，为开发实用的糖尿病患者新型无创血糖测试仪奠定了基础。
