Zidenberg-Cherr S, Han B, Dubick M A, Keen C L
Department of Nutrition, University of California, Davis 95616.
Toxicol Lett. 1991 Jun;57(1):81-90. doi: 10.1016/0378-4274(91)90122-m.
The influence of an animal's copper (Cu) and manganese (Mn) status on its response to ozone was investigated in weanling mice. Control, Cu-deficient and Mn-deficient mice were exposed continuously to 1.2 ppm O3 or filtered air for 7 days. In control mice, ozone exposure resulted in higher lung activities of CuZnSOD, MnSOD and GPx. In contrast, Mn-deficient mice did not display increases in lung MnSOD, CuZnSOD or GPx activities following ozone exposure. Similarly, ozone-induced increases in lung CuZn-SOD and MnSOD activities were not observed in Cu-deficient mice, although lung GPx activity was increased in these mice relative to their air-breathing controls. These results show that an animal's Cu and Mn status can influence its response to ozone, and the data suggest that Cu- and Mn-deprived animals may be more susceptible to long-term or repetitive ozone exposure.
在断奶小鼠中研究了动物的铜（Cu）和锰（Mn）状态对其对臭氧反应的影响。将对照、缺铜和缺锰小鼠连续暴露于1.2 ppm的臭氧或过滤空气中7天。在对照小鼠中，臭氧暴露导致肺中铜锌超氧化物歧化酶（CuZnSOD）、锰超氧化物歧化酶（MnSOD）和谷胱甘肽过氧化物酶（GPx）的活性升高。相比之下，缺锰小鼠在臭氧暴露后肺中MnSOD、CuZnSOD或GPx活性没有增加。同样，在缺铜小鼠中未观察到臭氧诱导的肺CuZn - SOD和MnSOD活性增加，尽管相对于呼吸空气的对照小鼠，这些小鼠的肺GPx活性有所增加。这些结果表明，动物的铜和锰状态可影响其对臭氧的反应，数据表明缺铜和缺锰的动物可能对长期或反复的臭氧暴露更敏感。
