细胞在协同的基质变形模式下的迁移。
Cell migration driven by cooperative substrate deformation patterns.
机构信息
School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.
出版信息
Phys Rev Lett. 2010 Apr 23;104(16):168104. doi: 10.1103/PhysRevLett.104.168104.
Abstract
Most eukaryotic cells sense and respond to the mechanical properties of their surroundings. This can strongly influence their collective behavior in embryonic development, tissue function, and wound healing. We use a deformable substrate to measure collective behavior in cell motion due to substrate mediated cell-cell interactions. We quantify spatial and temporal correlations in migration velocity and substrate deformation, and show that cooperative cell-driven patterns of substrate deformation mediate long-distance mechanical coupling between cells and control collective cell migration.
摘要
大多数真核细胞能够感知并响应其周围环境的力学特性。这会强烈影响胚胎发育、组织功能和伤口愈合过程中的细胞集体行为。我们使用可变形基底来测量由于基底介导的细胞-细胞相互作用而导致的细胞运动中的集体行为。我们定量分析了迁移速度和基底变形的空间和时间相关性，并表明协同的细胞驱动的基底变形模式介导了细胞之间的长程机械耦合，并控制了细胞的集体迁移。
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1
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Biophys J. 2008 Dec 15;95(12):6044-51. doi: 10.1529/biophysj.107.127662. Epub 2008 Sep 5.
2
Mechanism of shape determination in motile cells.运动细胞中形状确定的机制。
Nature. 2008 May 22;453(7194):475-80. doi: 10.1038/nature06952.
3
High resolution traction force microscopy based on experimental and computational advances.基于实验和计算进展的高分辨率牵引力显微镜。
Biophys J. 2008 Jan 1;94(1):207-20. doi: 10.1529/biophysj.107.113670. Epub 2007 Sep 7.
4
Swirling motion in a system of vibrated elongated particles.振动细长颗粒系统中的涡旋运动。
Phys Rev E Stat Nonlin Soft Matter Phys. 2007 May;75(5 Pt 1):051301. doi: 10.1103/PhysRevE.75.051301. Epub 2007 May 1.
5
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Phys Rev Lett. 2007 Apr 13;98(15):158102. doi: 10.1103/PhysRevLett.98.158102. Epub 2007 Apr 11.
6
Phase transition in the collective migration of tissue cells: experiment and model.组织细胞集体迁移中的相变：实验与模型
Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Dec;74(6 Pt 1):061908. doi: 10.1103/PhysRevE.74.061908. Epub 2006 Dec 22.
7
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8
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