Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Ocul Immunol Inflamm. 2010 Aug;18(4):305-13. doi: 10.3109/09273941003658292.
To evaluate whether intravitreal fluocinolone acetonide (FA) implantation (Retisert) leads to scleral thinning.
Scleral thickness was measured at the pars plana region (4 quadrants) with anterior segment OCT (Visante) in FA implanted eyes (18) with noninfectious posterior uveitis in comparison to eyes with prior vitrectomy (8), and normal eyes without prior surgery (30).
Mean scleral thickness in normal (nonsurgical) eyes was 0.99/0.93/0.88/0.86, and 0.92 mm in the inferonasal/inferotemporal/superotemporal/superonasal quadrants, and overall, respectively. Sclera was thinner in each quadrant of the FA implanted eyes compared to the fellow or nonsurgical eyes, although none reached statistical significance, as the differences were small. However, a few FA implanted eyes demonstrated more dramatic scleral thinning than others.
FA implant appears to lead to statistically nonsignificant scleral thinning overall with few exceptions. Clinicians should be aware of potential scleral thinning in select cases, important for reimplantation and long-term follow-up.
评估玻璃体内氟轻松醋酸酯（FA）植入（Retisert）是否导致巩膜变薄。
使用眼前节 OCT（Visante）在患有非传染性后葡萄膜炎的 FA 植入眼（18 只眼）的平面区域（4 象限）测量巩膜厚度，并与玻璃体切割术（8 只眼）和无先前手术史的正常眼（30 只眼）进行比较。
正常（非手术）眼的平均巩膜厚度分别为 0.99/0.93/0.88/0.86，鼻下/颞下/颞上/鼻上象限分别为 0.92mm，总体上分别为 0.92mm。与对侧眼或非手术眼相比，FA 植入眼的每个象限的巩膜均变薄，尽管差异均无统计学意义，但差异较小。然而，少数 FA 植入眼的巩膜变薄程度比其他眼更明显。
FA 植入物似乎导致总体上统计学上无显著巩膜变薄，但有少数例外。临床医生应注意在某些情况下可能发生的巩膜变薄，这对于再次植入和长期随访很重要。
