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[奥地利综合征:一名患有脑膜炎、肺炎和心内膜炎的患者]

[Austrian syndrome: a patient with meningitis, pneumonia and endocarditis].

作者信息

Schimmelpenninck Catrien A, Henkens Ivo R, Duchateau Christianne S J, van Buren Marjolijn

机构信息

HAGA Ziekenhuis, Afd. Interne Geneeskunde, Den Haag, The Netherlands.

出版信息

Ned Tijdschr Geneeskd. 2010;154:A1480.

Abstract

A 62-year-old man with a history of significant alcohol consumption presented with atypical neurological symptoms. Bacterial meningitis, caused by Streptococcus pneumoniae, was diagnosed with a 24-hour delay. Despite antibiotic treatment, the patient developed heart failure and multiple organ failure. He also had endocarditis with insufficient mitral and aortic valves. Subsequently, we found signs of a pulmonary infection. Because of an unsustainable haemodynamic situation, double heart valve replacement was considered necessary, despite the extremely high surgical risk and the extracardial infection foci showed by leukocyte scintigraphy. The patient died shortly after surgery. The triad of meningitis, pneumonia and endocarditis caused by Streptococcus pneumoniae is called the Austrian syndrome. This syndrome is rare and often has a serious course. It is strongly associated with asplenia, functional asplenia or hyposplenism, as occurs with alcohol abuse. Early recognition and a combination of antibiotic and surgical treatment is essential.

摘要

一名有大量饮酒史的62岁男性出现非典型神经症状。由肺炎链球菌引起的细菌性脑膜炎在24小时后才被诊断出来。尽管进行了抗生素治疗,患者仍出现心力衰竭和多器官衰竭。他还患有二尖瓣和主动脉瓣关闭不全的心内膜炎。随后,我们发现了肺部感染的迹象。由于血流动力学状况无法维持,尽管手术风险极高且白细胞闪烁扫描显示有心脏外感染灶,但仍认为有必要进行双心瓣膜置换术。患者术后不久死亡。由肺炎链球菌引起的脑膜炎、肺炎和心内膜炎三联征称为奥地利综合征。这种综合征很罕见,且病程往往严重。它与酗酒导致的无脾、功能性无脾或脾功能减退密切相关。早期识别以及抗生素和手术治疗相结合至关重要。

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