Rodríguez Nogué M, Gómez Arraiz I, Ara Martín G, Fraj Valle M M, Gómez Peligros A
Marta Rodríguez Nogué. CS Fernando el Católico, Calle Domingo Miral, s/n, 50009. Zaragoza. Spain.
Rev Esp Quimioter. 2019 Apr;32(2):98-113. Epub 2019 Mar 15.
The Austrian syndrome is a pathology caused by disseminated Streptococcus pneumoniae infection and characterized for the triad of pneumonia, endocarditis and meningitis. It has an estimated incidence of 0.9-7.8 cases per ten millions people each year, and a mortality of 32%. Alcohol abuse, as the main risk factor, appears only in four out of ten patients. Moreover, 14% of patientes do not have any risk factor. Two out of three patients are males and it occurs in the middle aged of life. It is more frequently on native valve, aortic valve is injured in the half of the cases. Severe regurgitation occurs in two per three patients. Appropriate antimicrobial treatment and early endocarditis surgery decrease mortality. It is possible that Austrian syndrome epidemiology is changing by the introduction of 13-valent pneumococcal conjugated vaccine in the children´s calendar.
奥地利综合征是一种由播散性肺炎链球菌感染引起的病理状况，其特征为肺炎、心内膜炎和脑膜炎三联征。据估计，其年发病率为每千万人中有0.9 - 7.8例，死亡率为32%。酗酒作为主要危险因素，仅在十分之四的患者中出现。此外，14%的患者没有任何危险因素。三分之二的患者为男性，发病于中年。它更常累及自身瓣膜，半数病例主动脉瓣受损。三分之二的患者出现严重反流。适当的抗菌治疗和早期心内膜炎手术可降低死亡率。由于在儿童免疫程序中引入了13价肺炎球菌结合疫苗，奥地利综合征的流行病学情况可能正在发生变化。
