Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, PR China.
Fitoterapia. 2010 Oct;81(7):838-43. doi: 10.1016/j.fitote.2010.05.006. Epub 2010 May 17.
The new cerebroside 1-O-(β-D-glucopyranosyl)-(2S, 3S, 4R, 8E)-2-[(2'R)-2'-hydroxytetracosenoilamino]-8-octadecene-1,3,4-triol (1) and ceramide (2S, 3S, 4R, 8E)-2-[(2'R)-2'-hydroxytetracosenoilamino]-8-octadecene-1,3,4-triol (2) were isolated from the ethyl acetate extract of the pollen of Brassica napus L. The structures of 1 and 2 were elucidated on the basis of chemical and spectroscopic method. Two new compounds were evaluated for activity in vitro assays for the cytotoxic activities against human tongue squamous carcinoma cell line (Tca8113).
从油菜花粉的乙酸乙酯提取物中分离得到了新的脑苷脂 1-O-(β-D-吡喃葡萄糖基)-(2S, 3S, 4R, 8E)-2-[(2'R)-2'-羟基二十四烷酰氨基]-8-十八烯-1,3,4-三醇（1）和神经酰胺 (2S, 3S, 4R, 8E)-2-[(2'R)-2'-羟基二十四烷酰氨基]-8-十八烯-1,3,4-三醇（2）。基于化学和光谱方法，阐明了 1 和 2 的结构。对这两种新化合物进行了体外细胞毒性试验，以评估其对人舌鳞癌细胞系（Tca8113）的活性。
