U 782 INSERM, Equipe implantation et dialogue cytokinique mère conceptus, 32 rue des Carnets et Hôpital Antoine Béclère Pavillon Jean Dalsace, 92141 Clamart France.
Reprod Biomed Online. 2007;14 Spec No 1:83-93. doi: 10.1016/S1472-6483(10)61462-9.
In a brief introduction, this review states why the presence of immune cells at the interface poses problems for an immunologist (Medawar paradigm). Different types of placentation are then discussed, and the various interactions with leukocytes, the extreme being with the equids where a certain degree of 'attack' is often seen. The limits of animal models when dealing with the human situation are emphasized. It is then stated why the various phases of pregnancy are different, and an analysis made of the cellular movements at the implantation, peri-implantation, immediate post-implantation and resorption windows in rodents. Details of the cellular components involved are given, as are hints for the human situation. The Th1/Th2 paradigm is described, with clinical examples, and its limits. Thus, the newly appraised dual role of natural killer (NK) cells is discussed, with examples in rodents and in humans (pre-eclampsia, implantation failure, abortion systems). Clinical data on the IL-12 /IL-18/NK tripod and implantation failure in humans are detailed.
在简短的介绍中，本篇综述阐述了为什么免疫细胞在界面处的存在会给免疫学家带来问题（梅达沃范式）。接着讨论了不同类型的胎盘形成，并讨论了与白细胞的各种相互作用，在某些马科动物中，这种相互作用非常明显。强调了在处理人类情况时动物模型的局限性。然后说明为什么妊娠的各个阶段不同，并对啮齿动物的着床、着床前、着床后即刻和吸收窗的细胞运动进行了分析。给出了涉及的细胞成分的详细信息，并暗示了人类的情况。描述了 Th1/Th2 范例，并结合临床实例说明了其局限性。因此，讨论了自然杀伤 (NK) 细胞新评估的双重作用，包括啮齿动物和人类的例子（先兆子痫、着床失败、流产系统）。详细介绍了人类中 IL-12/IL-18/NK 三脚架和着床失败的临床数据。
