Chaouat Gérard, Ledée-Bataille Nathalie, Dubanchet Sylvie
U 782 INSERM, Equipe implantation et dialogue cytokinique mère conceptus, 32 rue des Carnets et Hôpital Antoine Béclère Pavillon Jean Dalsace, 92141 Clamart, France.
Reprod Biomed Online. 2007 Feb;14(2):256-66. doi: 10.1016/s1472-6483(10)60796-1.
In a brief introduction, this review states why the presence of immune cells at the interface poses problems for an immunologist (Medawar paradigm). Different types of placentation are then discussed, and the various interactions with leukocytes, the extreme being with the equids where a certain degree of 'attack' is often seen. The limits of animal models when dealing with the human situation are emphasized. It is then stated why the various phases of pregnancy are different, and an analysis made of the cellular movements at the implantation, peri-implantation, immediate post-implantation and resorption windows in rodents. Details of the cellular components involved are given, as are hints for the human situation. The Th1/Th2 paradigm is described, with clinical examples, and its limits. Thus, the newly appraised dual role of natural killer (NK) cells is discussed, with examples in rodents and in humans (pre-eclampsia, implantation failure, abortion systems). Clinical data on the IL-12/IL-18/NK tripod and implantation failure in humans are detailed.
在简要介绍中，本综述阐述了免疫细胞在界面处的存在为何给免疫学家带来问题（梅达沃范式）。接着讨论了不同类型的胎盘形成，以及与白细胞的各种相互作用，其中最典型的是马科动物，在那里常可见到一定程度的“攻击”。强调了在处理人类情况时动物模型的局限性。然后说明了妊娠各阶段为何不同，并分析了啮齿动物在植入期、植入周围期、植入后即刻和吸收期窗口的细胞运动情况。给出了所涉及细胞成分的详细信息，以及对人类情况的提示。描述了Th1/Th2范式，并列举了临床实例及其局限性。因此，讨论了自然杀伤（NK）细胞新评估的双重作用，并列举了啮齿动物和人类的实例（先兆子痫、植入失败、流产机制）。详细介绍了关于白细胞介素-12/白细胞介素-18/NK三元组与人类植入失败的临床数据。
