绞股蓝中的达玛烷型三萜皂苷。

Dammarane saponins from Gynostemma pentaphyllum.

机构信息

Department of Biochemistry, Molecular Neuroscience Center, Biotechnology Research Institute, Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.

出版信息

Phytochemistry. 2010 Jul;71(10):1149-57. doi: 10.1016/j.phytochem.2010.04.003. Epub 2010 May 17.

DOI:10.1016/j.phytochem.2010.04.003

PMID:20483436

Abstract

Dammarane-type saponins (1-7), together with five known compounds, were isolated from the aerial parts of Gynostemma pentaphyllum. Compounds 1-4, 6 and 7 induced the phosphorylation of ERK protein in primary rat cortical neurons, which indicates their potential neuroactivity. On the other hand, no induction of ERK phosphorylation was observed for HEK293 cells following treatment with saponins 1, 3, 4 and 7.

摘要

达玛烷型皂苷（1-7）与五种已知化合物一起从绞股蓝的地上部分分离得到。化合物 1-4、6 和 7 诱导原代大鼠皮质神经元中 ERK 蛋白的磷酸化，这表明它们具有潜在的神经活性。另一方面，用皂苷 1、3、4 和 7 处理 HEK293 细胞后，未观察到 ERK 磷酸化的诱导。