Department of Oral and Maxillofacial Surgery, Toyohashi Municipal Hospital, 50 Hachiken Nishi, Aotake-Cho, Toyohashi, Aichi, Japan.
Int J Oral Maxillofac Surg. 2010 Oct;39(10):1020-3. doi: 10.1016/j.ijom.2010.04.008. Epub 2010 May 21.
Teratomas are embryonal tumours composed of diverse tissues from three germinal layers with variable levels of maturity. The authors report a female patient with a large immature epignathus. Prenatal diagnosis permitted a caesarean section and tracheotomy to be planned under ex utero intrapartum treatment for airway obstruction. The tumour was successfully controlled, even though it was impossible to distinguish from normal tissue because it lacked a pedicle and capsule, using multidisciplinary therapy, including a series of surgical treatments and adjuvant chemotherapy. This case suggested that the level of serum alpha fetoprotein might be a useful indicator after surgery. At present, after 4 years, no regrowth has been observed and the patient has no problems with respiration or swallowing.
畸胎瘤是由来自三个胚层的不同组织组成的胚胎性肿瘤，具有不同程度的成熟度。作者报告了一例女性患者，其患有巨大的未成熟颅咽管瘤。产前诊断使得可以在子宫内分娩治疗下进行剖宫产术和气管切开术，以预防气道阻塞。通过多学科治疗，包括一系列手术治疗和辅助化疗，成功地控制了肿瘤，尽管由于肿瘤缺乏蒂和包膜，与正常组织难以区分。该病例表明，手术后血清甲胎蛋白水平可能是一个有用的指标。目前，4 年后，未观察到肿瘤复发，患者呼吸和吞咽均无问题。
