Department of Microbiology and Immunology, Loyola University Medical Center, Maywood, IL 60153, USA.
J Immunol. 2010 Jun 15;184(12):6782-9. doi: 10.4049/jimmunol.1000155. Epub 2010 May 7.
Intestinal bacteria drive the formation of lymphoid tissues, and in rabbit, bacteria also promote development of the preimmune Ab repertoire and positive selection of B cells in GALT. Previous studies indicated that Bacillus subtilis promotes B cell follicle formation in GALT, and we investigated the mechanism by which B. subtilis stimulates B cells. We found that spores of B. subtilis and other Bacillus species, including Bacillus anthracis, bound rabbit IgM through an unconventional, superantigen-like binding site, and in vivo, surface molecules of B. anthracis spores promoted GALT development. Our study provides direct evidence that B cell development in GALT may be driven by superantigen-like molecules, and furthermore, that bacterial spores modulate host immunity.
肠道细菌驱动淋巴组织的形成，在兔子中，细菌也促进了前免疫 Ab 库的发展和 GALT 中 B 细胞的阳性选择。先前的研究表明，枯草芽孢杆菌促进了 GALT 中 B 细胞滤泡的形成，我们研究了枯草芽孢杆菌刺激 B 细胞的机制。我们发现，枯草芽孢杆菌和其他芽孢杆菌属的孢子，包括炭疽芽孢杆菌，通过非传统的超抗原样结合位点结合兔 IgM，并且在体内，炭疽芽孢杆菌孢子的表面分子促进了 GALT 的发育。我们的研究提供了直接的证据，表明 GALT 中的 B 细胞发育可能是由超抗原样分子驱动的，此外，细菌孢子还调节了宿主的免疫。
