Matsukawa T, Gotoh E, Uneda S, Miyajima E, Shionoiri H, Tochikubo O, Ishii M
Second Department of Internal Medicine, Yokohama City University School of Medicine, Japan.
Acta Physiol Scand. 1991 Feb;141(2):157-65. doi: 10.1111/j.1748-1716.1991.tb09064.x.
To determine whether there may be an abnormality in sympathetic nerve activity in response to physical and psychological stressors, we microneurologically recorded muscle sympathetic nerve activity in 11 normotensive and 9 borderline hypertensive, age-matched men. Supine blood pressure, plasma levels of epinephrine and norepinephrine and muscle sympathetic nerve activity were measured before and during a cold pressor test or a mental arithmetic test. The resting basal values of muscle sympathetic nerve activity, blood pressure and plasma epinephrine were significantly higher in the borderline hypertensives than in the normotensives (P less than 0.05). Plasma norepinephrine levels tended to be higher in the borderline hypertensives than in the normotensives but not to a significant extent (P less than 0.10). The cold test produced significantly exaggerated pressor and muscle sympathetic nerve responses (P less than 0.05) with a trend towards an increase in plasma norepinephrine (P less than 0.10) in the borderline hypertensives as compared with normotensives. The mental arithmetic test produced significantly enhanced pressor and plasma epinephrine responses in the borderline hypertensives as compared with the normotensives (P less than 0.05). During the mental arithmetic test the muscle sympathetic nerve activity decreased significantly in the normotensives (P less than 0.05) but not in the borderline hypertensives. These findings indicate that in people with borderline hypertension an abnormality exists in sympathetic nerve activity at rest and in response to stressors.
为了确定在应对身体和心理应激源时交感神经活动是否可能存在异常，我们采用微神经记录法，对11名血压正常和9名临界高血压的年龄匹配男性的肌肉交感神经活动进行了记录。在冷加压试验或心算试验之前及期间，测量了仰卧位血压、肾上腺素和去甲肾上腺素的血浆水平以及肌肉交感神经活动。临界高血压患者的肌肉交感神经活动、血压和血浆肾上腺素的静息基础值显著高于血压正常者（P<0.05）。临界高血压患者的血浆去甲肾上腺素水平往往高于血压正常者，但差异不显著（P<0.10）。与血压正常者相比，冷试验使临界高血压患者的升压和肌肉交感神经反应显著增强（P<0.05），血浆去甲肾上腺素呈升高趋势（P<0.10）。与血压正常者相比，心算试验使临界高血压患者的升压和血浆肾上腺素反应显著增强（P<0.05）。在心算试验期间，血压正常者的肌肉交感神经活动显著降低（P<0.05），而临界高血压患者则无此变化。这些发现表明，临界高血压患者在静息状态下以及应对应激源时交感神经活动存在异常。
