Letizia C, Cerci S, De Ciocchis A, D'Ambrosio C, Scuro L, Scavo D
Medical Pathology I, University of Rome La Sapiddenza, Italy.
J Hum Hypertens. 1995 Nov;9(11):903-7.
Endothelin-1 (ET-1) is a potent vasoconstrictor peptide derived from endothelium. The presence of ET-1 in human vascular endothelium and in the plasma suggests that it may play a role in the regulation of vascular tone and blood pressure (BP) in humans. The aim of this study was to evaluate the behaviour of plasma ET-1 in 10 normotensives (average 36.3 +/- 14.8 years) and 10 borderline hypertensives (average 42.0 +/- 11.7 years) before, during and after a standard cold pressor test. We also evaluated the behaviour of heart rate and BP at the same time. Our results demonstrated that the baseline (-10 and 0 min) plasma ET-1 values were identical for the two groups (8.6 +/- 5.8 and 8 +/- 4.7 pg/ml in normotensives; 7.8 +/- 2.7 and 7 +/- 2.4 pg/ml in borderline hypertensives). A statistically significant increment was verified 10 min after exposure to cold in the borderline hypertensive group (12.1 +/- 5.1 pg/ml) compared with the normotensives group (6.8 +/- 4.5 pg/ml; P < 0.05). In conclusion, our study demonstrated that after 10 min of cold pressor stimulus an increase of circulating ET-1 levels was seen in borderline hypertensives.
内皮素-1（ET-1）是一种源自内皮细胞的强效血管收缩肽。人类血管内皮和血浆中存在ET-1，这表明它可能在调节人类血管张力和血压（BP）中发挥作用。本研究的目的是评估10名血压正常者（平均年龄36.3±14.8岁）和10名临界高血压患者（平均年龄42.0±11.7岁）在标准冷加压试验前、试验期间和试验后的血浆ET-1变化情况。我们同时还评估了心率和血压的变化情况。我们的结果表明，两组的基线（-10分钟和0分钟）血浆ET-1值相同（血压正常者为8.6±5.8和8±4.7 pg/ml；临界高血压患者为7.8±2.7和7±2.4 pg/ml）。与血压正常者组（6.8±4.5 pg/ml）相比，临界高血压组在暴露于寒冷环境10分钟后，血浆ET-1出现统计学上的显著升高（12.1±5.1 pg/ml；P<0.05）。总之，我们的研究表明，在冷加压刺激10分钟后，临界高血压患者的循环ET-1水平升高。
