抗逆转录病毒治疗中断期间 HIV 推断的嗜性转换。
Switching of inferred tropism caused by HIV during interruption of antiretroviral therapy.
机构信息
Clinical Infectious Diseases, Tor Vergata University, Rome, Italy.
出版信息
J Clin Microbiol. 2010 Jul;48(7):2586-8. doi: 10.1128/JCM.02125-09. Epub 2010 May 19.
Abstract
After interruption of highly active antiretroviral therapy, 15 out of 53 patients with the X4 HIV strain had a significantly larger decrease in CD4(+) T cell count (P = 0.001) and shorter length of treatment interruption (P = 0.02) than patients with the R5 strain. At treatment resumption, HIV inferred tropism switched from the X4 strain to the R5 variant in 9 patients (60%). These patients had a prolonged length of treatment interruption compared to that of those who still carried the X4 strain.
摘要
在中断高效抗逆转录病毒治疗后，53 名携带 X4 艾滋病毒株的患者中有 15 名的 CD4(+)T 细胞计数明显下降（P = 0.001），中断治疗的时间也更短（P = 0.02），而携带 R5 株的患者则没有。在恢复治疗时，9 名（60%）患者的 HIV 推断嗜性从 X4 株转变为 R5 变体。与仍携带 X4 株的患者相比，这些患者的治疗中断时间更长。
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