高效抗逆转录病毒疗法抑制期间病毒储存库中的HIV-1 X4/R5共受体

HIV-1 X4/R5 co-receptor in viral reservoir during suppressive HAART.

作者信息

Soulié Cathia, Marcelin Anne-Geneviève, Ghosn Jade, Amellal Bahia, Assoumou Lambert, Lambert Sidonie, Duvivier Claudine, Costagliola Dominique, Katlama Christine, Calvez Vincent

机构信息

Department of Virology-EA2387, Pitié Salpêtrière Hospital, University Pierre et Marie Curie, Paris, France.

出版信息

AIDS. 2007 Oct 18;21(16):2243-5. doi: 10.1097/QAD.0b013e3282f0e3d0.

DOI:10.1097/QAD.0b013e3282f0e3d0

PMID:18090053

Abstract

As immune recovery during HAART is mainly caused by the expansion of X4-naive cells, we studied the evolution of HIV tropism in the reservoir of 34 patients receiving 48 weeks of HAART. No change in virus tropism was observed over time, but patients with X4 viruses had higher HIV-1 proviral DNA levels than patients with R5 viruses. This suggests that CCR5 antagonist activity should not be compromised in patients harbouring R5 viruses before starting HAART.

摘要

由于高效抗逆转录病毒疗法（HAART）期间的免疫恢复主要是由X4型初始细胞的扩增引起的，我们研究了34例接受48周HAART治疗患者的病毒库中HIV嗜性的演变。随着时间的推移，未观察到病毒嗜性的变化，但携带X4病毒的患者比携带R5病毒的患者具有更高的HIV-1前病毒DNA水平。这表明，在开始HAART之前，对于携带R5病毒的患者，不应损害CCR5拮抗剂的活性。