亚甲蓝在血清素综合征中的作用：系统评价。
The role of methylene blue in serotonin syndrome: a systematic review.
机构信息
correspondence and Aged Care Mental Health, Robina Hospital, Gold Coast Health Service District, Locked Bag 15, Robina, QLD 4226, Australia.
出版信息
Psychosomatics. 2010 May-Jun;51(3):194-200. doi: 10.1176/appi.psy.51.3.194.
BACKGROUND
A recent series of case reports has demonstrated a significant, previously unrecognized drug interaction between serotonin reuptake inhibitors (SRIs) and methylene blue (MB).
OBJECTIVE
The authors review the case reports and clinical audits relevant to this interaction and consider the diagnosis of serotonin syndrome in these cases.
METHOD
Articles were obtained from a systematic search of MEDLINE and PsychInfo databases, and from the bibliographies of relevant articles. Studies were considered relevant if the patient received MB and developed an acute confusional state, neuropsychiatric complications, or autonomic instability.
RESULTS
The review identified nine case reports and two retrospective reviews; 26 patients developed an acute confusional state after MB infusion; 24 of these patients were taking an SRI, and 1 was taking clomipramine. Serotonin syndrome was a possible diagnosis in all 25 of these patients.
CONCLUSION
SRIs can interact with MB, causing a serious adverse reaction consistent with serotonin syndrome.
背景
最近一系列病例报告表明，5-羟色胺再摄取抑制剂（SSRIs）与亚甲蓝（MB）之间存在显著的、以前未被认识到的药物相互作用。
目的
作者回顾了与这种相互作用相关的病例报告和临床审计，并考虑了这些病例中 5-羟色胺综合征的诊断。
方法
文章通过系统检索 MEDLINE 和 PsychInfo 数据库以及相关文章的参考文献获得。如果患者接受 MB 并出现急性意识混乱、神经精神并发症或自主不稳定，则认为研究相关。
结果
综述确定了 9 份病例报告和 2 份回顾性综述；26 名患者在 MB 输注后出现急性意识混乱；其中 24 名患者正在服用 SSRIs，1 名患者正在服用氯米帕明。所有 25 名患者的诊断均可能为 5-羟色胺综合征。
结论
SSRIs 可与 MB 相互作用，引起与 5-羟色胺综合征一致的严重不良反应。
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