Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Sci Transl Med. 2010 May 19;2(32):32ps23. doi: 10.1126/scitranslmed.3001082.
New data from Favre and colleagues strengthen the link between activation of the tryptophan oxidation (TOx) pathway--via the indoleamine 2,3-dioxygenase enzymes IDO1 and IDO2--and chronic inflammation in progressive HIV disease. It can now be appreciated that a pathogenic TOx activation cycle exists in HIV. TOx regulation is a therapeutic target for other diseases, such as cancer and autoimmune disorders. Here TOx control is examined with an eye to eventual therapeutic intervention in HIV disease.
法夫尔（Favre）及其同事的新数据强化了色氨酸氧化（TOx）途径的激活——通过色氨酸 2,3-双加氧酶（IDO1 和 IDO2）——与进行性 HIV 疾病中的慢性炎症之间的关联。现在可以理解，在 HIV 中存在致病性 TOx 激活循环。TOx 调节是治疗其他疾病（如癌症和自身免疫性疾病）的一个治疗靶点。在这里，我们研究了 TOx 控制，以期最终对 HIV 疾病进行治疗干预。
