National Institute of Infectious Diseases, Department of Dermatology, Nippon Medical School, Tokyo, Japan.
Dermatology. 2010 Aug;221(1):5-8. doi: 10.1159/000278232. Epub 2010 May 13.
Human papillomavirus type 7 (HPV-7) was originally identified in common warts of butchers. It has remained unclear, however, whether HPV-7 also induces other distinct types of cutaneous lesions. We observed similar keratoses on the groins of 2 patients. The lesions presented as multiple, smooth and small with little change in color from that of the adjacent skin and were diagnosed as condylomas. Their histological features were acanthosis, papillomatosis and parakeratosis with hyperkeratotic perinuclear vacuolation in the granular layer. By Southern blot analysis, HPV-7 DNA was identified in both condylomas. We conclude that HPV-7 infection causes condyloma. In addition, we discuss the long-held dogma regarding the association of HPV-7 with butcher's warts and highlight the potential need for clinicians to know causal HPV types in cutaneous lesions given the increased use of prophylactic HPV vaccines.
人乳头瘤病毒 7 型（HPV-7）最初在屠夫的寻常疣中被发现。然而，目前尚不清楚 HPV-7 是否也会引起其他不同类型的皮肤损伤。我们观察到 2 例患者腹股沟部位有类似的角化病。病变表现为多个、光滑和小的，与周围皮肤的颜色变化不大，被诊断为尖锐湿疣。它们的组织学特征为棘层肥厚、乳头瘤样增生和角化不良，颗粒层出现核周嗜酸性空泡。通过 Southern blot 分析，在两个尖锐湿疣中均发现了 HPV-7 DNA。我们得出结论，HPV-7 感染会导致尖锐湿疣。此外，我们讨论了长期以来 HPV-7 与屠夫疣相关的观点，并强调了鉴于预防性 HPV 疫苗的使用增加，临床医生了解皮肤损伤中因果 HPV 类型的潜在必要性。
