Hadjivassiliou Maria, Stefanaki Christina, Nicolaidou Electra, Bethimoutis George, Anyfantakis Vassilios, Caroni Chrysseis, Katsambas Andreas
Sexually Transmitted Infections Unit, Dermatology Department, Andreas Sygros Hospital, University of Athens, Athens, Greece.
Int J STD AIDS. 2007 May;18(5):329-34. doi: 10.1258/095646207780749574.
Our purpose was to investigate the human papillomavirus (HPV) type distribution using the Hybrid Capture 2 (HC2) Microplate assay in males. We tested a urethral swab from 550 HIV-negative males with genital warts and 64 HIV-negative males clinically free of genital warts, partners of HPV-infected females, using the HC2 Microplate assay. A perianal swab was also obtained from patients with perianal warts. In the first group, HPV DNA of any type was detected in 280 (50.9%) patients. Relatively few patients with urethral or perianal warts demonstrated a negative test (both P < 0.0001). Low-risk types were commoner, accounting for 60.0% of the HPV cases, high/intermediate-risk types accounted for 23.6%, while 46 men (16.4%) were infected with both types. Of 13 subjects (20.3%) of the second group who tested positive for HPV DNA, 61.5% were infected by low-risk types, 23.1% by high/intermediate-risk types and 15.4% had a dual infection. In conclusion, male partners of infected females and males with genital warts are predominantly infected by low-risk HPV types, but a substantial proportion is also or only affected by high-risk types.
我们的目的是使用杂交捕获2（HC2）微孔板检测法研究男性人乳头瘤病毒（HPV）的型别分布。我们使用HC2微孔板检测法对550名患有尖锐湿疣的HIV阴性男性以及64名临床上无尖锐湿疣的HIV阴性男性（HPV感染女性的性伴侣）的尿道拭子进行了检测。还从患有肛周湿疣的患者处获取了肛周拭子。在第一组中，280名（50.9%）患者检测到任何型别的HPV DNA。尿道或肛周湿疣患者中检测结果为阴性的相对较少（P均<0.0001）。低危型更为常见，占HPV病例的60.0%，高危/中危型占23.6%，而46名男性（16.4%）同时感染了这两种类型。在第二组检测HPV DNA呈阳性的13名受试者（20.3%）中，61.5%感染了低危型，23.1%感染了高危/中危型，15.4%为双重感染。总之，感染女性的男性性伴侣以及患有尖锐湿疣的男性主要感染低危型HPV，但也有相当比例同时或仅感染高危型。
