比较约旦烟民和非烟民的血浆天然抗凝剂（蛋白 C 和蛋白 S）水平。

Comparison of plasma levels of natural anticoagulants (protein C and protein S) among Jordanian smokers and non-smokers.

机构信息

Department of Pediatrics, Jordan University of Science and Technology, Irbid, Jordan.

出版信息

Acta Haematol. 2010;123(4):248-52. doi: 10.1159/000314670. Epub 2010 May 13.

DOI:10.1159/000314670

PMID:20484889

Abstract

BACKGROUND

Protein C (PC) with its cofactor free protein S (FPS) are important anticoagulants. Any defect in the PC system is a risk factor for venous thrombosis.

AIMS

To assess the effect of intensity of smoking, and the dose-response for the number of cigarettes smoked on PC and FPS plasma levels.

METHODS

A comparative study was designed and carried out on a convenient sample of 50 healthy non-smokers and 150 non-symptomatic Jordanian male smokers. PC and FPS levels were measured using an automated system (Stago Analyzer, USA).

RESULTS

The plasma level of PC among smokers was 7.2% lower than that among non-smokers (p = 0.02). Moreover, smokers had 15.6% lower circulating FPS than non-smokers (p = 0.001). Furthermore, data showed significant negative correlations between both PC and FPS levels and the intensity of smoking (r = -0.21%, r = -0.23%, respectively; p = 0.01) and the period of smoking (r = -0.15%, r = -0.23%, respectively; p = 0.01, 0.12, respectively).

CONCLUSIONS

The PC and FPS plasma levels were significantly lower in smokers than non-smokers. Both PC and FPS levels correlated inversely with the period and intensity of smoking, and FPS was more sensitive to smoking than PC.

摘要

背景

蛋白 C（PC）与其辅因子游离蛋白 S（FPS）是重要的抗凝剂。PC 系统的任何缺陷都是静脉血栓形成的危险因素。

目的

评估吸烟强度以及吸烟数量与 PC 和 FPS 血浆水平的剂量反应关系。

方法

设计并进行了一项便利样本的比较研究，纳入了 50 名健康不吸烟者和 150 名无症状的约旦男性吸烟者。使用自动系统（美国 Stago 分析仪）测量 PC 和 FPS 水平。

结果

吸烟者的 PC 血浆水平比不吸烟者低 7.2%（p = 0.02）。此外，吸烟者的循环 FPS 比不吸烟者低 15.6%（p = 0.001）。此外，数据显示 PC 和 FPS 水平与吸烟强度（r = -0.21%，r = -0.23%；p = 0.01）和吸烟时间（r = -0.15%，r = -0.23%；p = 0.01，0.12）呈显著负相关。