无症状下颌第三磨牙牙囊p63基因的病理变化及免疫表达：一项免疫组织化学研究
Pathological changes and immunoexpression of p63 gene in dental follicles of asymptomatic impacted lower third molars: an immunohistochemical study.
作者信息
Brkić Amila, Mutlu Sevcihan, Koçak-Berberoğlu Hülya, Olgaç Vakur
机构信息
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul University Capa, Istanbul, Turkey.
出版信息
J Craniofac Surg. 2010 May;21(3):854-7. doi: 10.1097/SCS.0b013e3181d809ab.
OBJECTIVE
The aim of this study was to examine the pathologic changes and immunoexpressivity of p63 gene in dental follicles (DFs) of asymptomatic partially and completely impacted lower third molars.
STUDY DESIGN
Clinical and radiologic examinations included 50 DFs with no signs of abnormal radiolucency (follicular space <2.5 mm), taken from 50 patients.
RESULTS
Histopathologic examinations of the specimens revealed 47 normal dental follicular tissues, 1 ameloblastoma, and 2 dentigerous cysts. p63 Immunoexpressivity was stronger in the DFs of the group with completely impacted teeth (64%),than it was in the case of DFs of the group with partially impacted teeth (40%).
CONCLUSIONS
Stronger p63 gene immunoexpression in the group with completely impacted teeth might be a consequence of bigger number of stem cells than it is in the case of the group with partially impacted teeth. This study also supports prophylactic removal of impacted teeth because of the development of pathologies associated with them.
目的
本研究旨在检查无症状部分和完全阻生下颌第三磨牙牙囊（DFs）中p63基因的病理变化和免疫表达情况。
研究设计
临床和放射学检查包括从50例患者中获取的50个无异常透射影像迹象（滤泡间隙<2.5 mm）的牙囊。
结果
标本的组织病理学检查显示47个正常牙囊组织、1例成釉细胞瘤和2例含牙囊肿。完全阻生牙组牙囊中p63的免疫表达（64%）强于部分阻生牙组牙囊（40%）。
结论
完全阻生牙组中p63基因免疫表达更强可能是因为其干细胞数量多于部分阻生牙组。本研究还支持因与之相关的病变发展而预防性拔除阻生牙。
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