Kadashetti Vidya, Patil Nanda, Datkhile Kailas, Kanetakar Sujata, Shivakumar K M
Department of Oral Pathology and Microbiology, Forensic Odontology, School of Dental Sciences, Krishna Institute of Medical Sciences Deemed University, Malkapur, Maharashtra, India.
Department of Pathology, Krishna Institute of Medical Sciences, Krishna Institute of Medical Sciences Deemed to be University, Malkapur, Maharashtra, India.
J Oral Maxillofac Pathol. 2020 May-Aug;24(2):273-278. doi: 10.4103/jomfp.JOMFP_203_19. Epub 2020 Sep 9.
Odontogenic keratocyst (OKC) is a benign intraosseous lesions (within the jaw bone) of odontogenic origin that account for about 10% of jaw cysts. They are characterized by an aggressive behavior with a relatively high recurrence rate. Early diagnosis and follow-up of the patient with OKC is important because the possibility of such patient there is develop to other features of Nevoid basal cell carcinoma syndrome in future. Considering the roles and effects of p53, p63 and proliferating cell nuclear antigen (PCNA) in cells proliferation, this study was designed.
To understand the behavior of epithelial cells in pathogenesis and biological aspects of OKC in diagnosis.
Immunohistochemical (IHC)technique was performed in 21 cases of OKCs.
Immunological stained p53 cells were mainly located in the suprabasal layers. p63 and PCNA-positive cells were found throughout the lining epithelium including basal and suprabasal cell layers. The intensity of staining was more in p63 and PCNA than the p53 expression of the cystic epithelial lining.
It is possible that the biological behavior of OKCs may be related to the suprabasal proliferative compartment in the cystic epithelium as observed. These proteins may participate in the regulation of epithelial cell differentiation. Taken together, these data may favor tumerigenesis on OKCs.
牙源性角化囊肿（OKC）是一种牙源性的良性骨内病变（位于颌骨内），约占颌骨囊肿的10%。它们具有侵袭性，复发率相对较高。对OKC患者进行早期诊断和随访很重要，因为这类患者未来有可能发展为痣样基底细胞癌综合征的其他特征。考虑到p53、p63和增殖细胞核抗原（PCNA）在细胞增殖中的作用和影响，设计了本研究。
了解上皮细胞在OKC发病机制和诊断生物学方面的行为。
对21例OKC病例进行免疫组织化学（IHC）技术检测。
免疫染色的p53细胞主要位于基底上层。在整个衬里上皮包括基底和基底上层细胞层中均发现p63和PCNA阳性细胞。p63和PCNA的染色强度高于囊性上皮衬里的p53表达。
如观察到的那样，OKC的生物学行为可能与囊性上皮中的基底上层增殖区室有关。这些蛋白质可能参与上皮细胞分化的调节。综上所述，这些数据可能支持OKC的肿瘤发生。
