Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Gut Liver. 2008 Jun;2(1):1-7. doi: 10.5009/gnl.2008.2.1.1. Epub 2008 Jun 30.
Autoimmune pancreatitis (AIP) is a peculiar type of chronic pancreatitis whose pathogenesis involves autoimmune mechanisms. The steroid responsiveness has a significant impact on the diagnosis of AIP because patients with AIP and pancreatic cancer share many clinical features. This review focuses on the treatment and relapse of AIP. The goal of AIP treatment is remission of symptoms, serology, radiologic changes, or histology, which also applies to relapse. Although it is generally agreed that steroids should be offered to AIP patients with active disease, there is no standardized steroid regimen for AIP and no consensus on the dose and duration of steroid induction and tapering schedule, and optimal duration and dose of maintenance therapy. Obtaining a consensus on the optimal treatment regimen is very important to reducing the relapse rate. In this review, we discuss the treatment regimens used in many centers.
自身免疫性胰腺炎（AIP）是一种特殊类型的慢性胰腺炎，其发病机制涉及自身免疫机制。类固醇反应性对 AIP 的诊断有重要影响，因为 AIP 和胰腺癌患者有许多共同的临床特征。本综述重点介绍 AIP 的治疗和复发。AIP 的治疗目标是缓解症状、血清学、影像学改变或组织学改变，这也适用于复发。尽管人们普遍认为应该为患有活动性疾病的 AIP 患者提供类固醇，但目前尚无 AIP 的标准化类固醇治疗方案，也没有关于类固醇诱导和减量方案的剂量和持续时间以及维持治疗的最佳持续时间和剂量的共识。就最佳治疗方案达成共识对于降低复发率非常重要。在本综述中，我们讨论了许多中心使用的治疗方案。
