Burry K A, Greenberg L H, Patton P E
Department of Obstetrics and Gynecology, Oregon Health Sciences University, Portland 97201-3098.
Am J Obstet Gynecol. 1991 Jun;164(6 Pt 1):1592-5; discussion 1595-6. doi: 10.1016/0002-9378(91)91441-x.
The endocrine response to controlled ovarian hyperstimulation was reviewed in 94 women undergoing in vitro fertilization during 114 cycles. The purpose of this review was to evaluate the effect of short-term oral contraceptive suppression on the recovery of pituitary gonadotropin function and subsequent controlled ovarian hyperstimulation. Seventy-three cycles (64%) were adequate for oocyte retrieval. In 41 cycles (36%) hyperstimulation was discontinued. The serum 17 beta-estradiol value in women with a poor response was 57 +/- 50 pg/ml on day 8 compared with 376 +/- 334 pg/ml in the women who completed in vitro fertilization (p less than 0.05). The majority of women (84.2%) had a prompt response to controlled ovarian hyperstimulation after short-term oral contraceptive suppression. Most discontinuations were due to dominant follicle selection or luteinizing hormone surge and not to oversuppression by short-term oral contraceptives. Clinical pregnancies occurred in 15 women (20.5% of harvests).
对94名在114个周期中接受体外受精的女性的控制性卵巢过度刺激的内分泌反应进行了回顾。本回顾的目的是评估短期口服避孕药抑制对垂体促性腺激素功能恢复及随后的控制性卵巢过度刺激的影响。73个周期（64%）适合取卵。41个周期（36%）的过度刺激被中止。反应较差的女性在第8天的血清17β-雌二醇值为57±50 pg/ml，而完成体外受精的女性为376±334 pg/ml（p<0.05）。大多数女性（84.2%）在短期口服避孕药抑制后对控制性卵巢过度刺激有迅速反应。大多数中止是由于优势卵泡选择或促黄体生成素激增，而非短期口服避孕药的过度抑制。15名女性发生临床妊娠（占取卵的20.5%）。
