Diandé S, Sangaré L, Kouanda S, Dingoumda B I, Traoré A S
National Tuberculosis Centre, Ouagadougou, Burkina Faso.
West Afr J Med. 2009 Nov-Dec;28(6):353-7. doi: 10.4314/wajm.v28i6.55020.
In Burkina Faso, there is no recent data about the level of drug resistance in Mycobacterium tuberculosis strains among newly diagnosed tuberculosis cases.
To provide an update of the primary drug resistance of mycobacterium tuberculosis among patients in Burkina faso.
Mycobacterium strains were identified in 323 newly diagnosed tuberculosis patients between April 2005 and September 2006, and their susceptibility to isoniazid, rifampicin, streptomycin, and ethambutol was determined according to the proportions method. Among these patients, 243 accepted voluntarily to be tested for antibodies to HIV.
The age range of the patients was 11 and 75 years and included 221 (68.4%) males and 102 (21.6%) females. The isolates included 314 (97.2%) M. tuberculosis, eight (0.3%) M. africanum and one M. bovis. Thirty-nine (12.4%) of the M. tuberculosis strains were resistant, with 7.3% resistant to one drug, 2.9% to two drugs, 0.3% to three drugs and 1.9% to four drugs. In total 3.2% of the isolates were multidrug-resistant (MDR). One isolate of M. africanum was resistant to all drugs while the single strain of M. bovis was sensitive to all the drugs. Among the 243 patients tested for HIV 77 were positive. However, there was no relationship between drug resistance and gender, age group or HIV serostatus of the patients.
The resistance rate of M. tuberculosis strains to all the four drugs tested (12.4%) and the rate of MDR (3.2%) are high. These results demand an increased effort by the National Tuberculosis Program to limit the spread of MDR strains of tuberculosis.
在布基纳法索，尚无关于新诊断肺结核病例中结核分枝杆菌菌株耐药水平的最新数据。
提供布基纳法索患者中结核分枝杆菌原发性耐药情况的最新信息。
2005年4月至2006年9月期间，对323例新诊断的肺结核患者的分枝杆菌菌株进行鉴定，并根据比例法测定其对异烟肼、利福平、链霉素和乙胺丁醇的敏感性。其中243例患者自愿接受HIV抗体检测。
患者年龄在11岁至75岁之间，包括221例（68.4%）男性和102例（21.6%）女性。分离菌株包括314例（97.2%）结核分枝杆菌、8例（0.3%）非洲分枝杆菌和1例牛分枝杆菌。39例（12.4%）结核分枝杆菌菌株耐药，其中7.3%对一种药物耐药，2.9%对两种药物耐药，0.3%对三种药物耐药，1.9%对四种药物耐药。总计3.2%的分离菌株为多重耐药（MDR）。1例非洲分枝杆菌分离株对所有药物耐药，而单株牛分枝杆菌对所有药物敏感。在接受HIV检测的243例患者中，77例呈阳性。然而，耐药性与患者的性别、年龄组或HIV血清学状态之间无关联。
结核分枝杆菌菌株对所有四种检测药物的耐药率（12.4%）和多重耐药率（3.2%）较高。这些结果要求国家结核病规划加大力度，以限制耐多药结核菌株的传播。
