Department of Neonatology, The Edmond and Lili Safra Children's Hospital, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Israel.
Pediatr Blood Cancer. 2010 Jul 15;55(1):145-8. doi: 10.1002/pbc.22514.
Although maternal thrombocytopenia during pregnancy is common, its effect on neonatal platelets has not yet been fully evaluated.
We retrospectively evaluated the rate of thrombocytopenia among 767 healthy term neonates (gestational age 37-42 weeks) born to 723 mothers with pregnancy-induced thrombocytopenia to define risk factors predicting thrombocytopenia in this group.
Thrombocytopenia was diagnosed in 2.2% of the infants. Multivariate analysis showed that infants with thrombocytopenia were more likely to be male, to be born at lower gestational age and to have lower birth weight associated with lower maternal platelets counts. Maternal platelet counts of 100-149 x 10(9)/L, 50-99 x 10(9)/L, and <50 x 10(9)/L corresponded respectively to 1.7%, 4.3%, and 12.5% of neonatal thrombocytopenia (P = 0.031).
Routine blood counts are recommended, in particular for male infants with low birth weight born to mothers with moderate-to-severe thrombocytopenia.
尽管妊娠期间母体血小板减少症较为常见，但尚未充分评估其对新生儿血小板的影响。
我们回顾性评估了 723 例妊娠诱导性血小板减少症母亲所生的 767 例健康足月新生儿（胎龄 37-42 周）的血小板减少症发生率，以确定该组中预测血小板减少症的危险因素。
诊断出 2.2%的婴儿存在血小板减少症。多变量分析表明，血小板减少症患儿更可能为男性，胎龄较低，出生体重较低，与母亲血小板计数较低相关。母亲血小板计数为 100-149×10^9/L、50-99×10^9/L 和<50×10^9/L 时，新生儿血小板减少症的发生率分别为 1.7%、4.3%和 12.5%（P=0.031）。
建议进行常规血常规检查，特别是对于母亲存在中重度血小板减少症且出生体重较低的男性婴儿。
