Burrows R F, Andrew M
Department of Obstetrics and Gynecology, McMaster University Medical Centre, Hamilton, Ontario, Canada.
Obstet Gynecol. 1990 Aug;76(2):234-8.
Infants of hypertensive mothers are at risk for a platelet count below 150 x 10(9)/L. To define this risk and assess maternal factors influencing the prevalence of neonatal thrombocytopenia, we collected cord blood samples from 520 infants of 607 consecutive hypertensive mothers with singleton pregnancies. The platelet count in cord blood from infants of hypertensive mothers was compared with that of a control normotensive population, and other comparisons were made among various maternal hypertensive groups. The rate of neonatal thrombocytopenia was 9.2% in hypertensive patients, compared with 2.2% in infants of normotensive mothers (P less than .00001). In the hypertensive group, preterm birth was the major risk factor for neonatal thrombocytopenia. Term infants of hypertensive mothers were no more likely to be thrombocytopenic than were control infants. Only two infants, both preterm, had cord platelet counts below 50 x 10(9)/L. Although obstetric interventions are not indicated, the rate of thrombocytopenia in preterm infants born to hypertensive women justifies neonatal scrutiny.
患有高血压的母亲所生的婴儿有血小板计数低于150×10⁹/L的风险。为了明确这种风险并评估影响新生儿血小板减少症患病率的母体因素，我们从607例连续单胎妊娠的高血压母亲所生的520名婴儿中采集了脐血样本。将高血压母亲所生婴儿的脐血血小板计数与正常血压对照人群的进行比较，并在不同的母体高血压组之间进行了其他比较。高血压患者中新生儿血小板减少症的发生率为9.2%，而正常血压母亲所生婴儿中的发生率为2.2%（P<0.00001）。在高血压组中，早产是新生儿血小板减少症的主要危险因素。高血压母亲的足月儿发生血小板减少症的可能性并不比对照婴儿更高。只有两名婴儿（均为早产儿）的脐血血小板计数低于50×10⁹/L。尽管未表明需要产科干预，但高血压妇女所生早产儿的血小板减少症发生率证明有必要对新生儿进行仔细检查。
