脂联素基因遗传变异与代谢综合征的关联：中国人群的病例对照研究和系统荟萃分析。
Association of genetic variants in the adiponectin gene with metabolic syndrome: a case-control study and a systematic meta-analysis in the Chinese population.
机构信息
Hubei Key Lab of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan, China.
出版信息
PLoS One. 2013 Apr 4;8(4):e58412. doi: 10.1371/journal.pone.0058412. Print 2013.
BACKGROUND
The prevalence of metabolic syndrome has been rising worldwide, including in China, but knowledge on specific genetic determinants of metabolic syndrome is very limited. A number of studies have reported that polymorphisms in the ADIPOQ gene are associated with metabolic syndrome in Chinese Han populations. However, data is still conflicting. The objective of this study was to examine the associations of the adiponectin genetic variants with metabolic syndrome by a case-control study and meta-analyses in Chinese.
METHODS
We first investigated the association of ADIPOQ rs2241766 (+45T>G in exon 2), rs266729 (-11377C>G in promoter) and rs1501299 (+276G>T in intron 2) polymorphisms with metabolic syndrome in a Hubei Han Chinese population with 322 metabolic syndrome patients and 161 normal controls recruited from the Yichang, Hubei. Then we comprehensively reviewed the association between ADIPOQ rs2241766/rs266729/rs1501299 and metabolic syndrome in the Chinese populations via a meta-analysis. The strength of association was assessed by odds ratios (ORs) with 95% confidence intervals (CI).
RESULTS
The G allele frequency of rs2241766 in metabolic syndrome patients was significantly higher than those of controls group (29.8% vs 23.3%, OR = 1.40, P = 0.033). The logistic regression analysis adjusted by gender and age showed a nominally significant association for rs2241766 GG+GT genotype (P = 0.065, OR = 1.55) and rs1501299 GG genotype in recessive model (OR = 1.54, P = 0.066). However, no association was observed for rs266729 in our sample. We identified thirteen studies for rs2241766 (2,684 metabolic syndrome patients and 2,864 controls), three studies for rs266729, and eleven studies for rs1501299 (2,889 metabolic syndrome patients and 3,304 controls) in Chinese. Meta-analysis indicated significant associations for the rs2241766 G allele (OR = 1.14, 95%CI = 1.05-1.24, P = 0.003), rs266729 GG+GT genotypes (OR = 0.80, 95%CI = 0.68-0.92, P = 0.003) and rs1501299 GG+TG genotypes (OR = 1.42, 95%CI 1.16-1.75, P = 0.001).
CONCLUSIONS
Our results demonstrated ADIPOQ as a pleiotropic locus for metabolic syndrome and its components in the Han Chinese population.
背景
代谢综合征的患病率在全球范围内呈上升趋势，包括中国，但对代谢综合征的特定遗传决定因素的了解非常有限。许多研究报告称，ADIPOQ 基因的多态性与中国汉族人群的代谢综合征有关。然而，数据仍然存在争议。本研究的目的是通过病例对照研究和荟萃分析，在中国人群中研究脂联素遗传变异与代谢综合征的相关性。
方法
我们首先在湖北汉族人群中研究了 ADIPOQ rs2241766(外显子 2 中的+45T>G)、rs266729(启动子中的-11377C>G)和 rs1501299(内含子 2 中的+276G>T)多态性与代谢综合征的相关性，该研究纳入了 322 例代谢综合征患者和 161 例正常对照，来自湖北宜昌。然后，我们通过荟萃分析全面回顾了 ADIPOQ rs2241766/rs266729/rs1501299 与中国人群代谢综合征之间的关系。用比值比(OR)及其 95%置信区间(CI)来评估关联的强度。
结果
代谢综合征患者 rs2241766 的 G 等位基因频率明显高于对照组(29.8%比 23.3%，OR=1.40，P=0.033)。经过性别和年龄调整的 logistic 回归分析显示，rs2241766 GG+GT 基因型(nominally significant association，P=0.065，OR=1.55)和 rs1501299 隐性模型 GG 基因型(rs1501299 GG 基因型，OR=1.54，P=0.066)与代谢综合征存在显著相关性。然而，我们在样本中没有观察到 rs266729 的相关性。我们在中国人群中确定了 13 项关于 rs2241766(2684 例代谢综合征患者和 2864 例对照)、3 项关于 rs266729 和 11 项关于 rs1501299(2889 例代谢综合征患者和 3304 例对照)的研究。荟萃分析表明，rs2241766 G 等位基因(OR=1.14，95%CI=1.05-1.24，P=0.003)、rs266729 GG+GT 基因型(OR=0.80，95%CI=0.68-0.92，P=0.003)和 rs1501299 GG+TG 基因型(OR=1.42，95%CI=1.16-1.75，P=0.001)与代谢综合征存在显著相关性。
结论
我们的结果表明，ADIPOQ 是汉族人群代谢综合征及其成分的一个多效性位点。
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