Zinchuk V V, Shul'ga E V
Eksp Klin Farmakol. 2010 Apr;73(4):18-22.
Effects of melatonin on the blood oxygen-carrying function and prooxidant - antioxidant balance in the organism were studied 12 h after lipopolysaccharide injection in rabbits. The treatment with melatonin (intraperitoneally in a dose of 4 mg/kg) before endotoxic lipopolysaccharide injection (intravenously 500 microg/kg) improved oxygen transport function of the blood, increased the hemoglobin-oxygen affinity, decreased nitrates/nitrites level, reduced the gain of free-radical processes, and increased the level of antioxidant protection factors in test animals. It is concluded that melatonin modulates the blood oxygen-carrying function and prooxidant - antioxidant balance through NO-dependent mechanisms, thus reducing the negative action of endotoxin on the organism.
研究了褪黑素对脂多糖注射12小时后家兔机体血液携氧功能及促氧化剂-抗氧化剂平衡的影响。在内毒素脂多糖注射（静脉注射500微克/千克）前用褪黑素（腹腔注射，剂量为4毫克/千克）进行治疗，可改善血液的氧运输功能，增加血红蛋白与氧的亲和力，降低硝酸盐/亚硝酸盐水平，减少自由基过程的增加，并提高试验动物体内抗氧化保护因子的水平。得出的结论是，褪黑素通过依赖一氧化氮的机制调节血液携氧功能和促氧化剂-抗氧化剂平衡，从而减少内毒素对机体的负面作用。
