松果体肽制剂Epithalamin对人和动物自由基过程的影响。
Effects of pineal peptide preparation Epithalamin on free-radical processes in humans and animals.
作者信息
Anisimov V N, Arutjunyan A V, Khavinson V K
机构信息
Saint-Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
出版信息
Neuro Endocrinol Lett. 2001;22(1):9-18.
OBJECTIVES
The review on our own data on the effect of the pineal peptide preparation Epithalamin on free radical processes in rodents and humans is presented in this paper.
RESULTS
The activity of Cu, Zn-superoxide dismutase (SOD) was found decreased in the brain of aged rats (30 months old) by 46.8% as compared to young animals. Concentration of Schiff's bases in the brain also went down with age (by 13.6%), while the level of dien conjugates (DC) and protein peroxidation (PPO) remained unchanged. General antioxidation activity (AOA) in the brain also remained stable with age. The liver of aged rats showed significant increase of Schiff's bases (by 27.1%) and PPO products (by 109.2%) and considerable decrease of SOD activity. The level of DC and general AOA in the liver remained unchanged with age. Considerable elevation of protein and lipid peroxidation products contents was registered in the blood serum of aged rats. At the same time, general AOA and SOD activity remarkably decreased. The results obtained evidence from both significant age-related alterations in the activity of free radical processes in animal organism and organic peculiarities of their dynamics. Application of peptide drug epithalamin suppressed significantly the intensity of peroxide chemoluminescence in the blood serum (2.8-fold) and lipid peroxide oxidation (LPO) expressed in the considerably decreased DC contents (4,1-fold). The contents of Schiff's bases showed only a tendency towards decrease (by 14.4%, p > 0.05) and PPO level remained unchanged. Epithalamin administration was followed by considerable (by 36.6%, p < 0.01) increase of general AOA and increased SOD activity (by 19.7%) in males. Epithalamin decreased significantly the contents of conjugated hydroperoxides and ketodienes in tissues of D.melanogaster females, increased catalase activity in drosophila males and females, and increased SOD activity in males of D.melanogaster by 41%. Humans reveal significant age-related decrease of antioxidation defence indices.
CONCLUSION
Epithalamin administration to patients with age-related pathology eliminates imbalance in prooxidation and antioxidation systems.
目的
本文对我们自己关于松果体肽制剂Epithalamin对啮齿动物和人类自由基过程影响的数据进行综述。
结果
与年轻动物相比，老年大鼠（30月龄）大脑中铜锌超氧化物歧化酶（SOD）的活性降低了46.8%。大脑中席夫碱的浓度也随年龄增长而下降（下降13.6%），而二烯共轭物（DC）和蛋白质过氧化（PPO）水平保持不变。大脑中的总体抗氧化活性（AOA）也随年龄保持稳定。老年大鼠肝脏中席夫碱显著增加（增加27.1%），PPO产物显著增加（增加109.2%），SOD活性显著降低。肝脏中DC水平和总体AOA随年龄保持不变。老年大鼠血清中蛋白质和脂质过氧化产物含量显著升高。与此同时，总体AOA和SOD活性显著降低。所获得的结果证明了动物机体中自由基过程活性与年龄相关的显著变化及其动力学的有机特性。肽类药物Epithalamin的应用显著抑制了血清中过氧化物化学发光强度（2.8倍）以及脂质过氧化（LPO），脂质过氧化表现为DC含量显著降低（4.1倍）。席夫碱含量仅呈现下降趋势（下降14.4%，p>0.05），PPO水平保持不变。给予Epithalamin后，雄性大鼠总体AOA显著增加（增加36.6%，p<0.01），SOD活性增加（增加19.7%）。Epithalamin显著降低了黑腹果蝇雌性组织中共轭氢过氧化物和酮二烯的含量，增加了果蝇雄性和雌性的过氧化氢酶活性，并使黑腹果蝇雄性的SOD活性增加了41%。人类抗氧化防御指标显示出与年龄相关的显著下降。
结论
给患有与年龄相关疾病的患者施用Epithalamin可消除氧化与抗氧化系统的失衡。
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