[姑息治疗团队所见的抗呕吐药引起的锥体外系症状]

[Antiemetic-induced extrapyramidal symptoms seen by our palliative care team].

作者信息

Nakanuno Ryuichi, Ito Taishin, Matsunaga Aki, Kawamoto Masashi

机构信息

Department of Anesthesiology and Critical Care, Hiroshima University Hospital, Hiroshima 734-8551.

出版信息

Masui. 2010 May;59(5):645-7.

PMID:20486582

Abstract

BACKGROUND

Antiemetic drugs, which are usually prescribed with opioids, occasionally induce extrapyramidal symptoms(EPS).

METHODS

In 109 patients treated with our palliative care team, we retrospectively investigated the appearance of antiemetic-induced EPS; its incidence, latent period, onset age, symptoms, causing agents and clinical outcomes.

RESULTS

EPS were observed in 6 of 109 patients. Six EPS patients, 2 men and 4 women, were between the age of 53 and 66 years. Prochlorperazine was used in all EPS patients. Two EPS were induced with unnecessary antiemetic drugs. Onset of EPS was from 11 to 162 days after beginning of antiemetic drugs. There were 5 patients with slow movement or speech, 3 patients with expressionless face, 2 patients with akathisia, and one patient with dysphagia. Five EPS patients were improved by using biperiden and one patient was by changing prochlorperazine to perospirone.

CONCLUSIONS

EPS were found in 6 of 109 patients during palliative care. We concluded that it was important not to forget the appearance of antiemetic-induced EPS when prescribing antiemetic drugs in palliative

摘要

背景

止吐药通常与阿片类药物一起使用，偶尔会诱发锥体外系症状（EPS）。

方法

在我们姑息治疗团队治疗的109例患者中，我们回顾性调查了止吐药诱发的EPS的出现情况；其发生率、潜伏期、发病年龄、症状、致病药物和临床结果。

结果

109例患者中有6例出现EPS。6例EPS患者，2例男性和4例女性，年龄在53至66岁之间。所有EPS患者均使用了氯丙嗪。2例EPS是由不必要的止吐药诱发的。EPS的发病时间为开始使用止吐药后11至162天。有5例患者出现运动或言语迟缓，3例患者面无表情，2例患者出现静坐不能，1例患者出现吞咽困难。5例EPS患者使用安坦后病情好转，1例患者将氯丙嗪换成螺哌隆后病情好转。