Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, USA.
J Am Chem Soc. 2010 Jun 16;132(23):7870-1. doi: 10.1021/ja103472a.
A unique alkene difunctionalization reaction that allows rapid construction of molecular complexity around the biologically relevant indole framework has been developed. The reaction proceeds with up to 87% yield, 99:1 er, and >20:1 dr. Evaluation of several of the compounds revealed promising anticancer activity against MCF-7 cells.
一种独特的烯键双官能化反应,可以在生物相关的吲哚骨架周围快速构建分子复杂性。该反应的产率高达 87%,ee 值为 99:1,dr 值大于 20:1。对几种化合物的评估显示出对 MCF-7 细胞有良好的抗癌活性。