Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, USA.
J Am Chem Soc. 2009 Dec 2;131(47):17074-5. doi: 10.1021/ja909030c.
A sequential intramolecular-intermolecular enantioselective alkene difunctionalization reaction has been developed which is thought to proceed through Pd-catalyzed quinone methide formation. The synthesis of new chiral heterocyclic compounds with adjacent chiral centers is achieved in enantiomeric ratios up to 99:1 and diastereomeric ratios up to 10:1.
发展了一种连续的分子内-分子间对映选择性烯烃双官能化反应，该反应被认为是通过 Pd 催化的醌甲醚形成来进行的。通过该方法可以高对映选择性（高达 99:1）和非对映选择性（高达 10:1）合成具有相邻手性中心的新型手性杂环化合物。
