Department of Neurosurgery, Tianjin Neurological Institute, General Hospital, Tianjin Medical University, Tianjin, China.
J Neurotrauma. 2010 Aug;27(8):1489-98. doi: 10.1089/neu.2009.1057.
Studies on the pathophysiology of subdural hematomas (SDH) have been primarily focused on the acute phase and associated cortical injury, whereas the course of hematoma absorption remains poorly understood. Using a rat model of SDH, we have specifically investigated the correlation between neovascularization of membrane and the rate of hematoma absorption. Using improved surgical techniques, we have reduced surgery-related injury and increased the rate of generating successful SDH to 71.4%. With this model, we demonstrate that hematoma absorption was slow in the first 4 days and accelerated thereafter. The absorption rate and recovery of sensorimotor deficits were closely associated with neovascularization in the neomembrane characterized by the formation of arachnoid granulation-like structures at the interface between the hematoma and encapsulating neomembrane. Our data suggest that neovascularization in the neomembrane plays a key role in hematoma absorption and neuronal recovery. Furthermore, measures to enhance neovascularization could have therapeutic potentials.
对硬膜下血肿（SDH）病理生理学的研究主要集中在急性期及其相关皮质损伤上，而血肿吸收的过程仍知之甚少。本研究使用大鼠 SDH 模型，特别研究了膜新生血管与血肿吸收速率之间的相关性。通过改进手术技术，我们减少了手术相关的损伤，并将成功生成 SDH 的比例提高到了 71.4%。使用该模型，我们证明血肿在最初的 4 天内吸收缓慢，此后加速。吸收速率和感觉运动功能障碍的恢复与新膜中的新生血管密切相关，新膜中的蛛网膜粒样结构在血肿和包裹性新膜的界面处形成。我们的数据表明，新膜中的新生血管在血肿吸收和神经元恢复中起着关键作用。此外，增强新生血管的措施可能具有治疗潜力。
