Division of Gene Regulation, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Eur J Clin Invest. 2010 Apr;40(4):370-4. doi: 10.1111/j.1365-2362.2010.02279.x.
microRNAs (miRNAs) are genes involved in normal development and cancer. They inhibit gene expression through interaction with 3'-untranslated regions of messenger RNAs, and are thought to control the expression of a large proportion of the protein-coding genome. However, it is becoming apparent that RNA-binding proteins (RBPs) control the biogenesis of miRNAs, their activity and stability. This indicates the existence of interplay between RBPs and miRNAs that affects gene expression and processes ranging from development, maintenance of stem cell phenotype and stress responses. Although miRNAs are prominent factors in cancer, little is known about how RBPs affect their cancerous function.
microRNAs (miRNAs) 是参与正常发育和癌症的基因。它们通过与信使 RNA 的 3'非翻译区相互作用来抑制基因表达，被认为可以控制大部分蛋白质编码基因组的表达。然而，现在越来越明显的是，RNA 结合蛋白 (RBPs) 控制着 miRNAs 的生物发生、活性和稳定性。这表明 RBPs 和 miRNAs 之间存在相互作用，影响从发育、干细胞表型维持到应激反应等多种基因表达和过程。虽然 miRNAs 是癌症中的重要因素，但对于 RBPs 如何影响它们的致癌功能知之甚少。
