Mahdavi Ali, Baradaran Nima, Nejat Farideh, El Khashab Mostafa, Monajemzadeh Maryam
Department of Neurosurgery, Children's Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
J Med Case Rep. 2010 May 20;4:143. doi: 10.1186/1752-1947-4-143.
To the best of our knowledge, the association between air travel and intra-tumoral hemorrhage in pediatric populations has never been described previously.
We report the case of a two-and-a-half-year-old Caucasian, Iranian boy with a hemorrhaging brain tumor. He had a posterior fossa midline mass and severe hydrocephalus. He had been shunted for hydrocephalus four weeks earlier and was subsequently referred to our center for further treatment. The hemorrhage occurred in an infra-tentorial ependymoma, precipitated by an approximately 700-mile air journey at a maximum altitude of 25,000 feet.
A pre-existing intra-cranial mass lesion diminishes the ability of the brain to accommodate the mild environmental disturbances caused by hypercarbia, increased venous pressure and reduced cerebral blood flow during long air journeys. This is supported by a literature review, based on our current knowledge of physiological changes during air travel.
据我们所知，此前从未有过关于航空旅行与儿科人群肿瘤内出血之间关联的描述。
我们报告一例患有出血性脑肿瘤的两岁半伊朗裔白种男孩。他有后颅窝中线肿块及严重脑积水。四周前因脑积水接受了分流手术，随后被转诊至我们中心接受进一步治疗。出血发生在幕下室管膜瘤中，是由一次最高海拔25000英尺、飞行距离约700英里的空中旅程诱发的。
预先存在的颅内占位性病变会削弱大脑在长时间空中旅行期间应对因高碳酸血症、静脉压升高和脑血流量减少所引起的轻度环境干扰的能力。基于我们目前对空中旅行期间生理变化的了解进行的文献综述支持了这一观点。
