Food Science Institute, Meiji Dairies Corporation, 540 Naruda, Odawara, Kanagawa 250-0862, Japan.
Br J Nutr. 2010 Oct;104(7):998-1006. doi: 10.1017/S000711451000173X. Epub 2010 May 21.
Immune senescence potentially leads to an increased risk of infections. It is desirable to augment the immune system and protect against infections by daily consumption of immunostimulatory food. The present study evaluated whether the intake of yoghurt fermented with Lactobacillus delbrueckii ssp. bulgaricus (L. bulgaricus) OLL1073R-1 has an effect on resistance to the common cold. We conducted two independent studies, in which fifty-seven (median age 74.5 years) and eighty-five healthy elderly individuals (median age 67.7 years) were participants. In each study, the subjects were divided into two groups based on age and sex and instructed to eat 90 g yoghurt or drink 100 ml milk once per d over an 8- or 12-week period. A meta-analysis of the results of these two independent studies showed the risk of catching the common cold was about 2.6 times lower (OR 0.39; P = 0.019) in the yoghurt group than in the milk group and the increase of natural killer cell activity was significantly higher in the yoghurt group than in the milk group (P = 0.028). In addition, the quality of life score for the 'eye/nose/throat' system after intake was significantly higher in the yoghurt group than in the milk group and the improvement of the score was correlated with the promotion of natural killer cell activity. In conclusion, consumption of yoghurt fermented with L. bulgaricus OLL1073R-1 augmented natural killer cell activity and reduced the risk of catching the common cold in elderly individuals.
免疫衰老可能会增加感染的风险。通过日常摄入免疫刺激食物来增强免疫系统和预防感染是很理想的。本研究评估了食用经过保加利亚乳杆菌(L. bulgaricus)OLL1073R-1 发酵的酸奶是否对预防普通感冒有影响。我们进行了两项独立的研究,共有 57 名(中位年龄 74.5 岁)和 85 名健康老年人(中位年龄 67.7 岁)参与。在每项研究中,根据年龄和性别将受试者分为两组,并指导他们在 8 或 12 周内每天食用 90 克酸奶或饮用 100 毫升牛奶。对这两项独立研究结果的荟萃分析表明,与牛奶组相比,酸奶组患普通感冒的风险降低了约 2.6 倍(OR 0.39;P = 0.019),且酸奶组自然杀伤细胞活性的增加明显高于牛奶组(P = 0.028)。此外,摄入酸奶后“眼睛/鼻子/喉咙”系统的生活质量评分明显高于牛奶组,评分的改善与自然杀伤细胞活性的增强相关。综上所述,食用经过保加利亚乳杆菌 OLL1073R-1 发酵的酸奶可增强自然杀伤细胞活性,降低老年人患普通感冒的风险。