National Tuberculosis Programme Madagascar, Department of Tuberculosis and Leprosy Control, Ministry of Health and Family Planning, Antananarivo, Madagascar.
Int J Tuberc Lung Dis. 2010 Jun;14(6):745-50.
A national survey of Mycobacterium tuberculosis resistance was conducted for the first time in Madagascar between October 2005 and July 2007.
To determine resistance rates among new and previously treated cases of pulmonary tuberculosis.
In a cluster sampling representative of the general population of the country, 1275 smear-positive tuberculosis patients recruited at 34 sites, 926 new patients and 87 previously treated patients underwent drug susceptibility testing against rifampicin (RMP), isoniazid (INH), streptomycin and ethambutol on Löwenstein-Jensen medium using the indirect proportion method.
Resistance among new cases was 6.5% (95%CI 4.9-8) and among previously treated cases it was 11.5% (95%CI 4.8-18.2). Monoresistance among new cases was 5.8% (95%CI 4.2-7.3), mainly to INH (3.7%). Multiresistance to INH and RMP was 0.2% (95%CI 0-0.5) among new cases and 3.4% (95%CI 0-7.2) among previously treated cases. No significant difference was noted with regard to sex or age.
The rates of resistance among new and previously treated cases remain relatively low in Madagascar.
2005 年 10 月至 2007 年 7 月，马达加斯加首次进行了全国性的结核分枝杆菌耐药性调查。
确定新的和以前治疗过的肺结核病例的耐药率。
采用整群抽样法，在该国具有代表性的一般人群中，在 34 个地点招募了 1275 例痰涂片阳性的肺结核患者，其中 926 例为新发病例，87 例为以前治疗过的病例，在 Löwenstein-Jensen 培养基上采用间接比例法进行利福平（RMP）、异烟肼（INH）、链霉素和乙胺丁醇的药敏试验。
新发病例的耐药率为 6.5%（95%CI 4.9-8），以前治疗过的病例的耐药率为 11.5%（95%CI 4.8-18.2）。新发病例的单耐药率为 5.8%（95%CI 4.2-7.3），主要为 INH（3.7%）。新发病例对 INH 和 RMP 的多耐药率为 0.2%（95%CI 0-0.5），以前治疗过的病例为 3.4%（95%CI 0-7.2）。性别或年龄方面无显著差异。
马达加斯加新发病例和以前治疗过的病例的耐药率仍然相对较低。
