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在瑞典斯德哥尔摩,哮喘和呼吸道症状的患病率是否已经达到了高峰?

Has the increase in the prevalence of asthma and respiratory symptoms reached a plateau in Stockholm, Sweden?

机构信息

Department of Internal Medicine, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

出版信息

Int J Tuberc Lung Dis. 2010 Jun;14(6):764-71.

Abstract

SETTING

An increase in the prevalence of asthma has previously been reported worldwide. However, the current trend is debatable.

OBJECTIVE

To assess changes in the prevalence of asthma and respiratory symptoms in a defined study area in Stockholm, Sweden, using identical methods.

DESIGN

A questionnaire was sent by mail in 1996 and 2007 to randomly selected subjects aged 20-69 years. On both occasions, 8000 subjects received the questionnaire, with response rates of 72% and 68%, respectively. Questions on asthma, respiratory symptoms, asthma medication and possible determinants were included. Logistic regression analysis was used to assess determinants.

RESULTS

Ever asthma increased from 8.7% in 1996 to 11.0% in 2007 and physician-diagnosed asthma from 7.6% to 9.3%. The proportion of asthma patients reporting one to two symptoms increased by 14% during the study period. There were few significant changes in the prevalence of respiratory symptoms: wheeze in the previous 12 months (15.9-17.3%), wheezing with breathlessness apart from cold (3.2-4.1%) and recurrent wheeze (8.3-6.8%). There was no major difference in the risk factor pattern between the surveys.

CONCLUSION

An increase in the prevalence of asthma with few symptoms as well as an unchanged prevalence of symptoms was demonstrated, which may indicate a change in diagnostic practices.

摘要

背景

哮喘的发病率在全球范围内呈上升趋势,但目前的趋势尚存在争议。

目的

采用相同的方法,评估瑞典斯德哥尔摩一个特定研究区域哮喘和呼吸道症状的流行率变化情况。

设计

1996 年和 2007 年,通过邮件向随机选择的 20-69 岁的受试者发送问卷。两次调查的应答率分别为 72%和 68%,各有 8000 名受试者收到问卷。问卷中包含哮喘、呼吸道症状、哮喘药物治疗以及可能的决定因素等问题。采用 logistic 回归分析评估决定因素。

结果

1996 年至 2007 年,既往哮喘的发病率从 8.7%增至 11.0%,经医生诊断的哮喘发病率从 7.6%增至 9.3%。报告 1-2 种症状的哮喘患者比例在此研究期间增加了 14%。呼吸道症状的流行率变化不大:过去 12 个月的喘息(15.9-17.3%)、除感冒外伴有呼吸困难的喘息(3.2-4.1%)和反复喘息(8.3-6.8%)。两次调查的危险因素模式差异不大。

结论

哮喘的发病率增加,但症状较轻,且症状的流行率保持不变,这可能表明诊断实践发生了变化。

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