血清素：脊椎动物视网膜中的一种候选神经递质。

Serotonin: A transmitter candidate in the vertebrate retina.

作者信息

Osborne N N, Nesselhut T, Nicholas D A, Cuello A C

机构信息

Nuffield Laboratory of Ophthalmology and Dept. of Pharmacology and Human Anatomy, Oxford University, England.

出版信息

Neurochem Int. 1981;3(2):171-6. doi: 10.1016/0197-0186(81)90037-1.

DOI:10.1016/0197-0186(81)90037-1

PMID:20487822

Abstract

It has been established by a combination of high performance liquid chromatographic and immunohistochemical methods that serotonin occurs in amacrine cell bodies and terminals situated in the inner plexiform layer of the frog retina, where enzymes for the synthesis of the same amine are also present. Potassium stimulation causes a release of previously accumulated radioactive serotonin by the retina. These findings support the opinion that serotonin is a retinal transmitter.

摘要

通过高效液相色谱法和免疫组织化学方法相结合已证实，5-羟色胺存在于青蛙视网膜内网状层的无长突细胞体和终末中，在那里也存在合成同一胺类的酶。钾离子刺激会使视网膜释放先前积累的放射性5-羟色胺。这些发现支持了5-羟色胺是视网膜递质的观点。