Focus on molecules: MERTK.
作者信息
Strick David J, Vollrath Douglas
机构信息
Department of Genetics, School of Medicine, Stanford University, 300 Pasteur Drive, Stanford, CA 94305-5120, USA.
出版信息
Exp Eye Res. 2010 Dec;91(6):786-7. doi: 10.1016/j.exer.2010.05.006. Epub 2010 May 19.
Abstract
摘要
相似文献
1
Focus on molecules: MERTK.聚焦分子：MERTK
Exp Eye Res. 2010 Dec;91(6):786-7. doi: 10.1016/j.exer.2010.05.006. Epub 2010 May 19.
2
Mertk drives myosin II redistribution during retinal pigment epithelial phagocytosis.在视网膜色素上皮细胞吞噬过程中，Mertk驱动肌球蛋白II重新分布。
Invest Ophthalmol Vis Sci. 2009 May;50(5):2427-35. doi: 10.1167/iovs.08-3058. Epub 2008 Dec 30.
3
Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium.受体MER酪氨酸激酶原癌基因（MERTK）对于双视黄醛向视网膜色素上皮的转运并非必需。
J Biol Chem. 2016 Dec 23;291(52):26937-26949. doi: 10.1074/jbc.M116.764563. Epub 2016 Nov 14.
4
MERTK signaling in the retinal pigment epithelium regulates the tyrosine phosphorylation of GDP dissociation inhibitor alpha from the GDI/CHM family of RAB GTPase effectors.视网膜色素上皮中的MERTK信号传导调节来自RAB GTP酶效应器的GDI/CHM家族的GDP解离抑制剂α的酪氨酸磷酸化。
Exp Eye Res. 2015 Nov;140:28-40. doi: 10.1016/j.exer.2015.08.006. Epub 2015 Aug 15.
5
Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in -associated retinitis pigmentosa.视网膜色素上皮炎症导致 - 相关的色素性视网膜炎中早期感光器变性。
Sci Adv. 2023 Jan 20;9(3):eade9459. doi: 10.1126/sciadv.ade9459.
6
Synergistic interaction of tubby and tubby-like protein 1 (Tulp1).塔比和塔比样蛋白 1（Tulp1）的协同相互作用。
Adv Exp Med Biol. 2014;801:503-9. doi: 10.1007/978-1-4614-3209-8_64.
7
MERTK interactions with SH2-domain proteins in the retinal pigment epithelium.MERTK 与视网膜色素上皮细胞中的 SH2 结构域蛋白相互作用。
PLoS One. 2013;8(2):e53964. doi: 10.1371/journal.pone.0053964. Epub 2013 Feb 4.
8
Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration.Ccr2和Cx3cr1在遗传性视网膜变性中的表达模式
J Neuroinflammation. 2015 Oct 12;12:188. doi: 10.1186/s12974-015-0408-3.
9
Cleavage of Mer tyrosine kinase (MerTK) from the cell surface contributes to the regulation of retinal phagocytosis.从细胞表面裂解Mer酪氨酸激酶（MerTK）有助于视网膜吞噬作用的调节。
J Biol Chem. 2015 Feb 20;290(8):4941-4952. doi: 10.1074/jbc.M114.628297. Epub 2014 Dec 23.
10
Tyro3 Modulates Mertk-Associated Retinal Degeneration.Tyro3调节与Mertk相关的视网膜变性。
PLoS Genet. 2015 Dec 11;11(12):e1005723. doi: 10.1371/journal.pgen.1005723. eCollection 2015 Dec.
引用本文的文献
1
Bisretinoid lipofuscin, fundus autofluorescence and retinal disease.双视黄醛脂褐质、眼底自发荧光与视网膜疾病。
Prog Retin Eye Res. 2025 Jul 8;108:101388. doi: 10.1016/j.preteyeres.2025.101388.
2
Design and Development of Novel Hybrids Based on Pyrrolo[2,1-f][1,2,4]Triazine and 1-(Methylpiperidin-4-yl) Aniline-Based Analogs: Exploring the Utility as Anticancer Agents via MERTK Inhibition.基于吡咯并[2,1-f][1,2,4]三嗪和1-(甲基哌啶-4-基)苯胺类似物的新型杂化物的设计与开发：通过抑制MERTK探索其作为抗癌剂的效用。
Chem Biol Drug Des. 2024 Dec;104(6):e70023. doi: 10.1111/cbdd.70023.
3
MERTK missense variants in three patients with retinitis pigmentosa.三位视网膜色素变性患者的 MERTK 错义变异。
Ophthalmic Genet. 2023 Feb;44(1):74-82. doi: 10.1080/13816810.2022.2113541. Epub 2022 Aug 29.
4
MERTK-Mediated LC3-Associated Phagocytosis (LAP) of Apoptotic Substrates in Blood-Separated Tissues: Retina, Testis, Ovarian Follicles.MERTK 介导的血分离组织（视网膜、睾丸、卵巢滤泡）中凋亡底物的 LC3 相关噬作用（LAP）。
Cells. 2021 Jun 9;10(6):1443. doi: 10.3390/cells10061443.
5
Bestrophinopathies: perspectives on clinical disease, Bestrophin-1 function and developing therapies.贝斯特病：临床疾病、贝斯特素-1功能及治疗进展的观点
Ther Adv Ophthalmol. 2021 Feb 27;13:2515841421997191. doi: 10.1177/2515841421997191. eCollection 2021 Jan-Dec.
6
The genetics of rod-cone dystrophy in Arab countries: a systematic review.阿拉伯国家的 rods-cone dystrophy 遗传学：系统评价。
Eur J Hum Genet. 2021 Jun;29(6):897-910. doi: 10.1038/s41431-020-00754-0. Epub 2020 Nov 13.
7
Abnormal mTORC1 signaling leads to retinal pigment epithelium degeneration.异常的 mTORC1 信号会导致视网膜色素上皮细胞退化。
Theranostics. 2019 Jan 30;9(4):1170-1180. doi: 10.7150/thno.26281. eCollection 2019.
8
Non-homologous recombination between Alu and LINE-1 repeats results in a 91 kb deletion in causing severe retinitis pigmentosa.Alu和LINE-1重复序列之间的非同源重组导致91 kb的缺失，引发严重的视网膜色素变性。
Mol Vis. 2018 Oct 18;24:667-678. eCollection 2018.
9
Bisretinoids mediate light sensitivity resulting in photoreceptor cell degeneration in mice lacking the receptor tyrosine kinase Mer.双视黄醛介导光敏感性，导致缺乏受体酪氨酸激酶 Mer 的小鼠感光细胞退化。
J Biol Chem. 2018 Dec 14;293(50):19400-19410. doi: 10.1074/jbc.RA118.005949. Epub 2018 Oct 23.
10
RPE phagocytic function declines in age-related macular degeneration and is rescued by human umbilical tissue derived cells.人脐带组织来源细胞可恢复年龄相关性黄斑变性中 RPE 的吞噬功能。
J Transl Med. 2018 Mar 13;16(1):63. doi: 10.1186/s12967-018-1434-6.
本文引用的文献
1
Novel mutations in MERTK associated with childhood onset rod-cone dystrophy.与儿童期发病的视杆-视锥营养不良相关的MERTK基因新突变。
Mol Vis. 2010 Mar 9;16:369-77.
2
Mertk drives myosin II redistribution during retinal pigment epithelial phagocytosis.在视网膜色素上皮细胞吞噬过程中，Mertk驱动肌球蛋白II重新分布。
Invest Ophthalmol Vis Sci. 2009 May;50(5):2427-35. doi: 10.1167/iovs.08-3058. Epub 2008 Dec 30.
3
Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-kappaB transcriptional activation.Mer受体酪氨酸激酶中的自磷酸化对接位点Tyr-867可使凋亡细胞吞噬的多种信号通路解离，并下调脂多糖诱导的NF-κB转录激活。
J Biol Chem. 2008 Feb 8;283(6):3618-3627. doi: 10.1074/jbc.M706906200. Epub 2007 Nov 26.
4
MERTK arginine-844-cysteine in a patient with severe rod-cone dystrophy: loss of mutant protein function in transfected cells.一名患有严重视杆-视锥营养不良患者的MERTK基因精氨酸844突变为半胱氨酸：转染细胞中突变蛋白功能丧失
Invest Ophthalmol Vis Sci. 2004 May;45(5):1456-63. doi: 10.1167/iovs.03-0909.
Zotero 插件