脉络膜和视网膜新生血管的动物模型。
Animal models of choroidal and retinal neovascularization.
机构信息
Department of Ophthalmology, Emory University, Atlanta, GA 30322, USA.
出版信息
Prog Retin Eye Res. 2010 Nov;29(6):500-19. doi: 10.1016/j.preteyeres.2010.05.003. Epub 2010 May 19.
Abstract
There have been numerous types of animal models of choroidal neovascularization (CNV) and retinal neovascularization (RNV). Understanding the pathobiology of CNV and RNV is important when evaluating and utilizing these models. Both CNV and RNV are dynamic processes. A break or defect in Bruchs' membrane is necessary for CNV to develop. This may be induced with a laser, mechanically via surgery, or in the setting of transgenic mice. Some of the transgenic mouse models spontaneously develop RNV and/or retinal angiomatous proliferation (RAP)-like lesions. The pathogenesis of RNV is well-known and is generally related to ischemic retinopathy. Models of oxygen-induced retinopathy (OIR) closely resemble retinopathy of prematurity (ROP). The streptozotocin (STZ) rat model develops features similar to diabetic retinopathy. This review summarizes general categories and specific examples of animal models of CNV and RNV. There are no perfect models of CNV or RNV and individual investigators are encouraged to choose the model that best suits their needs.
摘要
已经有许多种脉络膜新生血管（CNV）和视网膜新生血管（RNV）的动物模型。在评估和利用这些模型时，了解 CNV 和 RNV 的病理生物学特性非常重要。CNV 和 RNV 都是动态的过程。Bruch 膜的破裂或缺陷是 CNV 发展所必需的。这可以通过激光诱导、手术机械性诱导或在转基因小鼠中诱导。一些转基因小鼠模型会自发地发展出 RNV 和/或视网膜血管瘤样增殖（RAP）样病变。RNV 的发病机制是众所周知的，通常与缺血性视网膜病变有关。氧诱导的视网膜病变（OIR）模型与早产儿视网膜病变（ROP）非常相似。链脲佐菌素（STZ）大鼠模型发展出类似于糖尿病性视网膜病变的特征。这篇综述总结了 CNV 和 RNV 的一般类别和具体的动物模型例子。没有完美的 CNV 或 RNV 模型，鼓励个别研究人员选择最适合他们需求的模型。
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