Pu Ning, Li Siyu, Wu Hao, Zhao Na, Wang Kexin, Wei Dong, Wang Jiale, Sha Lulu, Zhao Yameng, Tao Ye, Song Zongming
Department of Ophthalmology, Henan Eye Hospital, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, China.
College of Medicine, Zhengzhou University, Zhengzhou 450001, China.
Antioxidants (Basel). 2025 May 8;14(5):561. doi: 10.3390/antiox14050561.
Age-related retinopathy is one of the leading causes of visual impairment and irreversible blindness, characterized by progressive neuronal and myelin loss. The damages caused by oxidation contributes to the hallmarks of aging and represents fundamental components in pathological pathways that are thought to drive multiple age-related retinopathies. Quercetin (Que), a natural polyphenol abundant in vegetables, herbs, and fruits, has been extensively studied for its long-term antioxidative effects mediated through diverse mechanisms. Additionally, Que and its derivatives exhibit a broad spectrum of pharmacological characteristics in the cellular responses of age-related retinopathy induced by oxidative stress, including anti-inflammatory, anti-neovascularization, regulatory, and neuroprotective effects in autophagy and apoptosis processes. This review mainly focuses on the antioxidative mechanisms and curative effects of Que treatment for various age-related retinopathies, such as retinitis pigmentosa, diabetic retinopathy, age-related macular degeneration, and glaucoma. Furthermore, we discuss emerging technologies and methods involving Que and its derivatives in the therapeutic strategies for age-related retinopathies, highlighting their promise for clinical translation.
年龄相关性视网膜病变是视力损害和不可逆失明的主要原因之一，其特征是神经元和髓鞘进行性丧失。氧化造成的损害促成了衰老的特征，并代表了被认为驱动多种年龄相关性视网膜病变的病理途径的基本组成部分。槲皮素（Que）是一种天然多酚，大量存在于蔬菜、草药和水果中，其通过多种机制介导的长期抗氧化作用已得到广泛研究。此外，槲皮素及其衍生物在氧化应激诱导的年龄相关性视网膜病变的细胞反应中表现出广泛的药理学特性，包括在自噬和凋亡过程中的抗炎、抗血管生成、调节和神经保护作用。本综述主要关注槲皮素治疗各种年龄相关性视网膜病变（如色素性视网膜炎、糖尿病性视网膜病变、年龄相关性黄斑变性和青光眼）的抗氧化机制和疗效。此外，我们还讨论了槲皮素及其衍生物在年龄相关性视网膜病变治疗策略中的新兴技术和方法，强调了它们在临床转化方面的前景。
