制剂前研究——含铝佐剂疫苗的下一个进展。 - Suppr

Preformulation studies--The next advance in aluminum adjuvant-containing vaccines.

作者信息

Hem Stanley L, HogenEsch Harm, Middaugh C Russell, Volkin David B

机构信息

Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907-2091, USA.

出版信息

Vaccine. 2010 Jul 12;28(31):4868-70. doi: 10.1016/j.vaccine.2010.05.007. Epub 2010 May 18.

DOI:10.1016/j.vaccine.2010.05.007

PMID:20488265

Abstract

摘要

相似文献

Preformulation studies--The next advance in aluminum adjuvant-containing vaccines.制剂前研究——含铝佐剂疫苗的下一个进展。

Vaccine. 2010 Jul 12;28(31):4868-70. doi: 10.1016/j.vaccine.2010.05.007. Epub 2010 May 18.

Potentiation of the immune response to non-adsorbed antigens by aluminum-containing adjuvants.含铝佐剂对非吸附抗原免疫反应的增强作用。

Vaccine. 2007 Jan 15;25(5):825-33. doi: 10.1016/j.vaccine.2006.09.039. Epub 2006 Sep 25.

Immunogenicity in mice of anthrax recombinant protective antigen in the presence of aluminum adjuvants.炭疽重组保护性抗原在铝佐剂存在下对小鼠的免疫原性。

Vaccine. 2005 Mar 14;23(16):1993-9. doi: 10.1016/j.vaccine.2004.10.014.

Comparison of the effects of five adjuvants on the antibody response to influenza virus antigen in guinea pigs.五种佐剂对豚鼠流感病毒抗原抗体反应影响的比较。

Lab Anim Sci. 1995 Aug;45(4):420-6.

An aluminium adjuvant in a vaccine is an acute exposure to aluminium.疫苗中的铝佐剂会使人急性接触铝。

J Trace Elem Med Biol. 2020 Jan;57:57-59. doi: 10.1016/j.jtemb.2019.09.010. Epub 2019 Sep 18.

Activation of dendritic cells and induction of CD4(+) T cell differentiation by aluminum-containing adjuvants.含铝佐剂对树突状细胞的激活及CD4(+) T细胞分化的诱导作用。

Vaccine. 2007 Jun 6;25(23):4575-85. doi: 10.1016/j.vaccine.2007.03.045. Epub 2007 Apr 19.

Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation.含铝佐剂的物理化学性质与免疫增强之间的关系。

Expert Rev Vaccines. 2007 Oct;6(5):685-98. doi: 10.1586/14760584.6.5.685.

[Adjuvants for human vaccines].[人类疫苗佐剂]

Pharm Unserer Zeit. 2008;37(1):42-51. doi: 10.1002/pauz.200700250.

Mechanism of immunopotentiation by aluminum-containing adjuvants elucidated by the relationship between antigen retention at the inoculation site and the immune response.通过接种部位抗原滞留与免疫应答之间的关系阐明含铝佐剂的免疫增强机制。

Vaccine. 2010 Apr 30;28(20):3588-94. doi: 10.1016/j.vaccine.2010.02.085. Epub 2010 Mar 5.

Increased immunogenicity of recombinant Ad35-based malaria vaccine through formulation with aluminium phosphate adjuvant.通过与磷酸铝佐剂配制提高基于重组Ad35的疟疾疫苗的免疫原性。

Vaccine. 2007 Aug 29;25(35):6501-10. doi: 10.1016/j.vaccine.2007.06.019. Epub 2007 Jun 29.

引用本文的文献

Vaccines combining slow delivery and follicle targeting of antigens increase germinal center B cell clonal diversity and clonal expansion.将抗原缓慢递送与卵泡靶向相结合的疫苗可增加生发中心B细胞的克隆多样性和克隆扩增。

bioRxiv. 2024 Aug 19:2024.08.19.608655. doi: 10.1101/2024.08.19.608655.

Analytical Insights into Protein-Alum Interactions and Their Impact on Conformational Epitope.蛋白质-明矾相互作用及其对构象表位影响的分析洞察

Pharmaceutics. 2024 Mar 19;16(3):420. doi: 10.3390/pharmaceutics16030420.

Aluminum hydroxide adjuvant diverts the uptake and trafficking of genetically detoxified pertussis toxin to lysosomes in macrophages.氢氧化铝佐剂将基因解毒的百日咳毒素的摄取和转运转移到巨噬细胞的溶酶体中。

Mol Microbiol. 2022 May;117(5):1173-1195. doi: 10.1111/mmi.14900. Epub 2022 Apr 7.

Short-term and longer-term protective immune responses generated by subunit vaccination with smallpox A33, B5, L1 or A27 proteins adjuvanted with aluminum hydroxide and CpG in mice challenged with vaccinia virus.以铝佐剂和 CpG 增强的天花 A33、B5、L1 或 A27 蛋白亚单位疫苗在接种牛痘病毒的小鼠中产生的短期和长期保护免疫应答。

Vaccine. 2020 Aug 27;38(38):6007-6018. doi: 10.1016/j.vaccine.2020.07.018. Epub 2020 Jul 30.

Comparative efficacy of two leading candidate ricin toxin a subunit vaccines in mice.两种主要候选蓖麻毒素A亚基疫苗在小鼠体内的比较疗效

Clin Vaccine Immunol. 2013 Jun;20(6):789-94. doi: 10.1128/CVI.00098-13. Epub 2013 Mar 20.

Adsorption of recombinant poxvirus L1-protein to aluminum hydroxide/CpG vaccine adjuvants enhances immune responses and protection of mice from vaccinia virus challenge.重组痘病毒 L1 蛋白吸附到氢氧化铝/CpG 疫苗佐剂上增强了免疫反应，并保护小鼠免受牛痘病毒攻击。

Vaccine. 2013 Jan 2;31(2):319-26. doi: 10.1016/j.vaccine.2012.11.007. Epub 2012 Nov 12.

Protein antigen adsorption to the DDA/TDB liposomal adjuvant: effect on protein structure, stability, and liposome physicochemical characteristics.蛋白抗原吸附到 DDA/TDB 脂质体佐剂上：对蛋白结构、稳定性和脂质体物理化学特性的影响。

Pharm Res. 2013 Jan;30(1):140-55. doi: 10.1007/s11095-012-0856-8. Epub 2012 Sep 6.

Formulation of a killed whole cell pneumococcus vaccine - effect of aluminum adjuvants on the antibody and IL-17 response.一种灭活全细胞肺炎球菌疫苗的配方——铝佐剂对抗体和白细胞介素-17反应的影响。

J Immune Based Ther Vaccines. 2011 Jul 29;9:5. doi: 10.1186/1476-8518-9-5.

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Preformulation studies--The next advance in aluminum adjuvant-containing vaccines.

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