Division of Pulmonary and Critical Care Medicine, Yale University School of Medicine, 333 Cedar Street, PO Box 208057, New Haven, CT 06520-8057, USA.
Clin Chest Med. 2010 Jun;31(2):203-20. doi: 10.1016/j.ccm.2010.02.010.
Cardiovascular disease has been the leading cause of death since 1900. Strategies for cardiovascular disease and prevention have helped to reduce the burden of disease, but it remains an important public health challenge. Therefore, understanding the underlying pathophysiology and developing novel therapeutic approaches for cardiovascular disease is of crucial importance. Recognizing the link between sleep and cardiovascular disease may represent one such novel approach. Obstructive sleep apnea (OSA), a common form of sleep-disordered breathing, has a high and rising prevalence in the general adult population, attributable in part to the emerging epidemic of obesity and enhanced awareness. OSA has been independently linked to specific cardiovascular outcomes such as hypertension, stroke, myocardial ischemia, arrhythmias, fatal and nonfatal cardiovascular events, and all-cause mortality. Treatment of OSA may represent a novel target to reduce cardiovascular health outcomes.
自 1900 年以来，心血管疾病一直是导致死亡的主要原因。心血管疾病和预防策略有助于减轻疾病负担，但它仍然是一个重要的公共卫生挑战。因此，了解心血管疾病的潜在病理生理学并开发新的治疗方法至关重要。认识到睡眠与心血管疾病之间的联系可能代表了这样一种新方法。阻塞性睡眠呼吸暂停（OSA）是一种常见的睡眠呼吸障碍，在普通成年人群中的患病率很高且呈上升趋势，部分原因是肥胖的流行和人们对其认识的提高。OSA 与特定的心血管结局独立相关，如高血压、中风、心肌缺血、心律失常、致命和非致命心血管事件以及全因死亡率。OSA 的治疗可能代表降低心血管健康结局的一个新目标。
