Institut Pasteur, Molecular Biology of the Gene in Extremophiles Unit, 75724 Paris Cedex 15, France.
Virology. 2010 Aug 15;404(1):1-4. doi: 10.1016/j.virol.2010.04.020. Epub 2010 May 20.
Recently a unique mechanism of virion release was discovered in Archaea, different from lysis and egress systems of bacterial and eukaryotic viruses. It involves formation of pyramidal structures on the host cell surface that rupture the S-layer and by opening outwards, create apertures through which mature virions escape the cell. Here we present results of a protein analysis of Sulfolobus islandicus cells infected with the rudivirus SIRV2, which enable us to postulate SIRV2-encoded protein P98 as the major constituent of these exceptional cellular ultrastructures.
最近，在古菌中发现了一种独特的病毒粒子释放机制，与细菌和真核病毒的裂解和出芽系统不同。它涉及在宿主细胞表面形成金字塔结构，破坏 S-层，然后向外打开，在细胞表面形成孔道，成熟的病毒粒子由此逸出细胞。在这里，我们介绍了感染 rudivirus SIRV2 的 Sulfolobus islandicus 细胞的蛋白质分析结果，使我们能够推测 SIRV2 编码的蛋白 P98 是这些特殊细胞超微结构的主要成分。
